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e235 otics, Piperacillin/Tazobactam was most commonly used (23 cases, 33.8%) and Cefepime was next. (20 cases, 29.4%). Successful response to initial antibiotics was 5 cases (72.4%) in MDI, 30 cases (85.7%) in CDI, and 24 cases (92.3%) in UF. Mortality rate was 4.4% and all death was related to infection. Conclusion: There were no evident differences of clinical features between the 1st period and the 2nd period. But we found two specific clinical features. The rate of successful response to initial antibiotics was the highest in UF (92.3%). It means that we need to change or add the empirical antibiotics if we could guess the site of infection rather than use the recommended antibiotics in 2002 IDSA guidelines. And extremely high portion of gram-positive bacteria (85.7%) were isolated compared with other clinics in Korea. We think it might be an unique clinical feature in Jeju island. In the future, empirical antibiotics that cover the grampositive bacteria for NF may need to be routinely used in Jeju island.

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