A summary of the major considerations in the design of LMFBR core restraint systems is presented. A discussion of these considerations is given using the design features and environment of the Clinch River Breeder Reactor Plant core restraint system design. A comparison of core restraint performance with an alternate concept is provided. Conclusions are drawn on the direction of current and future core restraint system designs.vms ggont B

A new route to pyrido[1,2‐b]indazole and its derivatives is described and the nitration of the parent compound is reported. The formation of δ‐carbolines as byproducts is discussed.

The last stage of grinding concrete surfaces is performed by floaters with solid grinding discs, where the working element consists of a solid wheel. The working element uses the full surface of the disc, ensuring maximum geometrical effectiveness. The disc rotates around its center and at the same time, it is in a steady progressive movement. The effectiveness chart Sg for the solid disc with common kinematic parameters has a local minimum at the inside and zero values on the edges of the machining area. Increasing the effectiveness of the machining at the edges is accomplished by overlapping areas of machining in subsequent cycles. Increasing the local minimum effectiveness can be achieved by applying a two-element disc consisting of concentric machining elements -ring and wheel. Optimal selection of the rotation speed and wheel radius gives better uniformity of two-element disc machining in comparison to the solid disc. The grinding uniformity of areas with widths smaller than the diameter of the disc can be achieved by machining them with the biggest effect uniformity area of action. The best effect can be achieved by using both methods at the same time.

No abstract

Rare genetic variants may play a prominent role in schizophrenia. We report on the to date largest whole exome sequencing study of schizophrenia case-control samples from related populations and combine with other available sequence data, analysing in total 34,084 individuals (14,302 cases). Three genes showed significant association at FDR < 0.10 (SETD1A, TAF13 and MKI67) and gene-set analyses highlighted the involvement of the synaptome and excitatory neurons, and demonstrated shared architecture with high-functioning autism.