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The conversion of fortimicin E, a minor metabolite from the Micromonospora olivoasterospora fermentation which also produces fortimicin A and fortimicin B, to four 4-N-aminoacylfortimicins E was accomplished.The new 4-N-aminoacylfortimicins E showed only weak antimicrobial activity against several Gram-negative and Gram-positive microorganisms.

Erythromycin (1) is a well established macrolide antibiotic of major therapeutic importance because of its effective antibacterial profile and safety. These properties have prompted several research groups to explore modifications of 1 or isolation of newmacrolides1^w ith the hopes of discovering analogs with improved properties over the parent compound.Onenovel macrolide resulting from such efforts is 2, which was synthesized from erythromycin A5) and later isolated from Saccharopolyspora sp. L53-18 and named sporeamicin A.6>7) Compound 2 is more acid stable than 1, has higher oral bioavailability and shows better efficacy8) in animal models of bacterial infections.