SYNOPSIS Trimethoprim is a synthetic compound which arrests the step in bacterial purine synthesis immediately succeeding that interfered with by sulphonamides.Acting alone it inhibits the growth of a wide range of bacteria in generally much lower concentrations than sulphonamides. Its action with a sulphonamide is strongly synergic and bactericidal.Studies are described of suitable cultural conditions, methods of testing sensitivity, and acquired resistance.Some clinical results of its use are reported in respiratory tract infections, Gram-negative septicaemia, and urinary tract infections, and further therapeutic possibilities are discussed.

No abstract

SUMMARYThe diversity of colonial types of Pseudomonas aeruginosa which may be encountered is described, together with a series of biochemical tests and the application of serological and pyocine typing which are of use in identifying atypical strains. These methods are particularly recommended for strains which do not form pigment. It is suggested that absence of pigment production even on special media does not preclude the possibility that a strain is P. aeruginosa.

No abstract

No abstract