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A novel environmentally benign procedure for the synthesis of 2-aryl-or 2-hetaryl-4(3H)-quinazolinones by condensation of anthranilamide with various aromatic aldehydes in polyethylene glycol under microwave irradiation has been developed. In contrast with other reported methods, this procedure provides the corresponding quinazolinones with good to high yields and purity, in very short reaction times and without the use of an oxidant.

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Use of Azalactones in a "Pictet-Spengler-Like" Reaction. Stereoselective Synthesis of 1,3,4-Substituted Tetrahydro-β-carbolines.-Conformationally constrained tryptamines (I) undergo a Pictet-Spengler-like reaction with the azlactones (II) in refluxing HCl to give the corresponding tetrahydro-β-carbolines (III) in moderate to good yield. -(EZQUERRA, J.; LAMAS, C.; PASTOR, A.; ALVAREZ, P.; VAQUERO, J.

1997 stereochemistry stereochemistry (general, optical resolution) O 0030 03 -060 4-Benzyl-2,3-didehydroprolinate (IV) as a Homochiral Template for Michael Additions. Synthesis of Enantiopure α-Allokainoids (VII), β-Kainoids (XX), 2,3-Methanoprolines (XVI) and Other 3,4 Disubstituted Prolines (XIII). -Compound (IV) undergoes Michael additions with stabilized carbanions and cuprates to give exclusively the enantiopure all-trans 3,4-disubstituted prolinates. The high stereoselectivity observed is caused by the C-4 substituent of the Michael acceptor. -(EZQUERRA, J.; ESCRIBANO, A.; RUBIO, A.; REMUINAN, M. J.; VAQUERO, J.