1 The effect of a new xanthine derivate 1-5' oxohexyl-3-methyl-7-proplyxanthine (HWA 285) was studied on heart performance in dogs and rabbits and on regional blood flow in rabbits. 2 Heart performance (cardiac output and dPldt max) in dogs was increased. Cardiac work (calculated as CO x mean BP) was not changed in dogs and did not change or was slightly decreased in rabbits. Heart rate was increased in dogs and unchanged in rabbits. 3 Blood pressure decreased slightly in dogs, and more markedly in rabbits. Total peripheral resistance was decreased in both species. 4 Regional blood flow (studied by use of 15 arm labelled microspheres) was increased in the heart, brain and skeletal muscle; the increase was dose-dependent in the range 0.3, 1.0 and 3.0 mg HWA 285 per kg intravenously. The highest dose produced a 2 fold decrease in the peripheral resistance in the brain, a 2.5 fold decrease in the heart and 4 fold decrease in skeletal muscle.5 The drugs preferentially dilated small (7 to 10 ,um) rather than larger (12 to 17 ,um) arterioles; 9 Am microspheres were found in the outflowing blood after application of the drug, and the calculated blood flow increases were smaller, or absent, as compared with values obtained with 15 ,um microspheres..

The effects of vasopressin (ADH) were tested on the cardiovascular system of 7 catheterized barbitone-anaesthetized beagle dogs.ADH, as a constant intravenous infusion for 10 min at 0.01 and 0.1 IU/kg/min, induced a dose-dependent increase of mean arterial blood pressure (MAP). At the higher dose there was a reversal of the effect 30 min after the primary increase. Similar changes were observed for left ventricular peak pressure (LVP).Heart rate (HR) and dP/dtmax showed a significant dose-dependent decrease, while total peripheral resistance (TPR) and the contraction period t-dP/dt showed a dose-dependent increase; all reaching their maximum alterations at the end of infusion, with a slow decline thereafter.Cardiac output index (COD was strongly reduced with clear dose-relationship, whereas stroke volume index (SVI) remained unaffected by the low dose and only showed a slight reduction at the higher dose. The parameter VeE was significantly reduced parallel to HR, while Vpm dropped at both doses with lesser significance.The time index t-Vpm consequently was elongated at the low dose. For the high dose there were two subsequent elevations with some similarity to the time course of MAP and LVP.Ejection time (ET) increased as did left ventricular end-diastolic pressure (LVEDP) and left ventricular end-systolic volume (LVESV). Dose-dependence was absent for the LVEDP elevation seen after discontinuing the infusion, and an inverse dose relationship occurred following the 30th rain for ET and the 45th min for both LVEDP and LVESV.Cardiac work (CW) declined in a dose-dependent manner. Left ventricular oxygen consumption (MVO2) was reduced for both doses with a lack of dosedependence following the infusion of the hormone.The antidiuretic hormone (ADH), a nonapeptide from the posterior pituitary with its site of action at the distal nephron, is also known as adiuretine or vasopressin. Its release can be stimulated by stress condi-905

Abstract-Activity of Carnigen on the cardiovascular system, following intraduodenal and intravenous application, was investigated in normotone and hypotone dogs anaes thetized with sodium pentobarbital, 35-40 mg/kg intraperitoneally. Intraduodenal application of 1 and 3 mg Carnigen/kg caused an increase in blood pressure and tachy cardia. The total peripheral resistance was lessened, in normotone as well as hypotone dogs, whereas the cardiac output and stroke volume were augmented.A rise in myocardial inotropy and cardiac work in combination with a moderate increase in left ventricular 02 consumption also occurred as result of the action of Carnigen. An increase in the central and peripheral venous pressure was registered during continuous infusion of Carnigen. Coronary flow was also raised, in a dose dependent manner within the range of 0.1 to 1 mg Carnigen/kg i.v. The rise in arterial blood pressure is due to an increase in cardiac output, resulting from the positive inotropic action of this compound on the myocardium.The reduction in arterial resistance can be ex plained on the basis of a possible interaction between the inosine, released from Carnigen, and the adenosine already present in the system. Carnigeni), one of the pharmacons introduced for therapy of hypotonic cardiovascular disorders, was observed to have a long lasting cardiovascular activity following enteral administration in experimental animals (1).As blood pressure raising properties of Carnigen, not only in normotone but in particular in hypotone animals were observed, we attempted to determine the cardiovascular activity of this preparation following intraduodenal and intravenous administration on animals with experimentally lowered blood pressure. MATERIALS AND METHODSPure bred Beagle and mongrel dogs of both sexes were anaesthetized with sodium pentobarbital (35-40 mg/kg i.p.) and heparinized with 2 mg heparin/kg i.v. The animals were divided into the following groups: 1) Normotone animals (Beagles, n=6) 2) Animals were placed in an experimental state of hypotension by continuous infusion of 0.007+0.002 mg/kg/min sodium nitroprusside infused through the femoral vein (Beagles, n=7) 3) Animals which were brought into a state of lowered blood pressure by an acute reduction in blood 1) Carnigen (Hoechst AG) Suprifene : 1-(4'-Hydroxyphenyl)-2-methylamino-propanol-(1)-HC l and a nucleotide containing heart muscle extract.

Blood gases, acid-base balance and hematological parameters (RBC, PCV and Hb) were measured in adult rats of both sexes. The use of ether and fentanyl had a very little effect on the blood gases and acid-base balance. The induction of pentobarbitone anesthesia, however, was followed by a significant increase in PCO2 and TCO2, while the pH value decreased.

Zusammenfassung Bei 33 Beagle‐Hunden, die klinisch keine Erkrankungen zeigten, wurde die Auswirkung von Na‐Pentobarbital (40 mg/kg KG i. p.) und Na‐Thiopental (25 mg/kg KG i. v.) auf den Säure‐Basen‐Status untersucht. Bei den Blutanalysen bedienten wir uns der Meßeinheit ABL1 (Blutgas‐Automat/Radiometer Kopenhagen. Unter Na‐Pentobarbital‐Narkose wurden im arteriellen Blut folgende Mittelwerte (n = 22) bestimmt: Po2 = 83,4 mm Hg, Pco2 = 44,9 mm Hg, pH = 7,30, O2 Vol% = 17,5, O2SA T = 93,0%, Hb = 16,1 g%. Die mit Na‐Thiopental narkotisierten Beagle (n = 11), wiesen im arteriellen Blut folgende Werte auf. PO2 = 79,1 mm Hg, Pco2 = 37,9 mm Hg, pH = 7,32, O2 Vol % = 16,6, O2SAT = 93,1%, Hb = 14,5 g%. Summary The effect of Na‐pentobarbital and Na‐thiopental on the acid‐base status of the blood in the Beagle The effect of Na‐Pentobarbital (40 mg/kg b. w. i. p.) and Na‐Thiopental (25 mg./kg. b. w. i. p.) on the blood acid‐base status was investigated in 33 pure bred beagle‐dogs. Blood analyses were done with the apparatus of “Radiometer Copenhagen — ABL”. The changes resulting in the measured blood acid‐base status — parameters can be summarized as follows: Na‐Pentobarbital — anaesthetic (n = 22), arterial mean values: Po2 = 83,4 mm. Hg, Pco2 = 44.9 mm. Hg, pH = 7.30, O2. Vol. % = 17.5, O2 SAT = 93.0%, Hb = 16.1 g.%. Na‐Thiopental‐anaesthetic (n = 11), arterial mean values: Po2 = 79.1 mm. Hg, Pco2 = 37.9 mm. Hg, pH = 7.32, O2 Vol. % = 16.6, O2 SAT = 93.1%, Hb = 14.5 g.%. Résumé L'effet du thiopental de sodium sur le statut acido‐basique dans le sang de chiens “Beagle” On a examiné l'effet du pentobarbital de sodium (40 mg/kg de poids i. p.) et du thiopental de sodium (25 mg/kg de poids i. v.) sur le statut acidobasique chez 33 chiens “Beagle” ne présentant aucun symptôme clinique. On a utilisé l'unité de mesure ABL 1 pour les analyses sanguines (Blutgas‐Automat/Radiometer Kopenhagen). Les valeurs moyennes suivantes (n = 22) ont été déterminées dans le sang artériel sous narcose au pentobarbital de sodium: Po2 = 83,4 mm Hg, Pco2 = 44,9 mm Hg, pH = 7,30, O2 Vol% = 17,5, O2 SAT = 93,0%, Hb = 16,1 g%. Les valeurs suivantes (n = 11) ont été obtenues avec une narcose au thiopental de sodium: Po2 = 79,1 mm Hg, Pco2 = 37,9 mm Hg, pH = 7,32, O2 Vol% = 16,6, O2 SAT = 93,1%, Hb = 14,5 g%. Resumen El efecto de tiopental sódico sobre el estado ácido‐básico en la sangre de perros beagle Se examinó en 33 perros beagle, los cuales no mostraban enfermedades clínicas, la repercusión de pentobarbital sódico (40 mg./kg. PC i. p.) y de tiopental sódico (25 mg./kg. PC i. v.) sobre el estado ácido‐básico. En los análisis de sangre nos valimos de la unidad de medida ABL 1 (autómata gaseoso sanguíneo/Radiometer Copenhague). Bajo narcosis pentobarbital‐Na se verificaron en la sangre arterial los valores medios (n = 22) siguientes: Po = 83.4 mm Hg, Pco2 = 44.9 mm Hg, pH = 7.30, O2 Vol.% = 17.5, O2 SAT = 93.0%, Hb = 16.1 g%. Los beagles (n = 11) narcotizados con tiopental‐Na ostentaban en la sangre arterial los valores siguientes: Po2 = 79.1 mm Hg, ...