This paper summarizes the experimental investigation of influence of process parameters on surface quality and dimensional accuracy of slots milled in titanium alloy TC4. Samples were milled using a 10 mm HXT coated monolith end mill for HSM milling of superalloys and titanium alloys. Process parameters, such as rotational speed, feed rate, and depth of cut were selected based on the Taguchi L9 method. After machining samples were measured, including surface quality parameters such as roughness, waviness and dimensional deviations. Measurement results indicate that within inspected parameter range rotational speed to feed ratio has a greater influence on surface quality than the depth of cut while having less influence on dimensional accuracy.