Only perimeter and bulkiness showed positive correlations with nasal esthetics. The group of parameters used to assess nostril morphology had neither significant correlation with-nor predictive power for-esthetics. Thus, an assessment of the entire nasal surface topography in three dimensions needs to be completed and assessed with respect to predictability of nasal esthetics.

Objective: The purpose of this study was to assess the ability of shape parameters of nasal morphology to predict esthetics in individuals with complete unilateral cleft lip and palate (CUCLP). Methods: This retrospective study involved 28 patients with repaired CUCLP. Nostril morphology was analyzed using nose casts and a video-imaging technique. Calculated shape parameters included area, perimeter, centroid, angle of the principal axis, major and minor moments of area, anisometry, bulkiness, lateral offset, and three-dimensional internostril angles. Esthetics was assessed using a panel of six orthodontists who rated nasal esthetics from frontal, lateral, basal, and three-quarters view slides and from nose casts. Correlations between esthetics and the shape parameters were completed using the entire group as well as using two statistically determined subsets: those with the best and those with the worst esthetics. Results: Nasal esthetics was related to only the perimeter and bulkiness parameter ratios. Symmetry of the perimeters between the right and left nostrils positively correlated with better esthetics using the entire sample group while symmetry of bulkiness between the right and left nostrils positively correlated with better esthetics using both the entire sample group and the best and worst subsets. Conclusions: Only perimeter and bulkiness showed positive correlations with nasal esthetics. The group of parameters used to assess nostril morphology had neither significant correlation with—nor predictive power for—esthetics. Thus, an assessment of the entire nasal surface topography in three dimensions needs to be completed and assessed with respect to predictability of nasal esthetics.

No abstract

The purpose of this study was to evaluate the effect of therapeutic insulin-like growth factor-I (IGF-I) administration on the mechanical properties of bone in mature ovariectomized rats. Eighty-eight female Sprague-Dawley rats (aged 4 months) were obtained, 56 of which were ovariectomized (OVX) and the remainder shamoperated (control). After 10 weeks, 8 control and 80VX rats were sacrificed, and IGF~I therapy (0.2 mg/kg, 5 d/wk) commenced for half of the remaining OVX rats. Sacrifice ef 8 rats from each group occurred 3, 6 and 12 weeks after therapy began. One femur, both humeri, and several lumbar vertebrae were dissected out, cleaned, and dried for transport. Dual-energy x-ray absorptiometry, density measurement, histomorphometry and mechanical testing were performed on the bones. IGF-I therapy did not increase the density or cross-sectional area in long bones, but it did increase the strength of the humeri in 3-point bending and the ultimate shear stress of femora in torsion (compared with the OVX group). In addition, the masses and densities of long bones from rats treated with IGF-I were increasing with time (unlike the OVX values). IGF-I therapy had no restorative effect on vertebrae; all parameters (including mechanical properties in compression) were unchanged from the OVX values and significantly less than control values. This suggests that IGF-I may preferentially affect cortical (rather than cancellous) bone. Acknowledgements: This work was performed in conjunction with Klaus MUller of Ciba-Geigy AG, Switzerland, and supported by Ciba-Geigy Canada and the Medical Research Council of Canada. PTu701 EFFECT OF FLUORIDE THERAPY ON BONE MhNERAL DENSITY IN WOMEN FROM A RELIGIOUS COMMUNITY. MAILAND D. SCANNER -BONE DENS[TY DEPARTMENT. ROSARIO. ARGENTINARegaining boo.c ma~ in menopause constitutes an issue of major interest into the modern medicine. On the other hand, it is also known that the speed and extend of bone loss, is largely dependent on the life conditions; i.e., dirt, to which people are exposed.Prellminat 7 ObServations made in our Department demonstrated that 18 of 31 women helcoging to a religioos community O~.C) had a marked loss of boon mass, which appeared earlier and more intense than age-matched control women living in the same area, (100%, ostaoporotic religious had menopause). In explaining this finding we assume that lack of physlcal activity; or sun exposure, along with the dietary deficit of milk, fruits and vegetables could account for their decreased bone mineral density (BMD). It is also thought that administration of combined therapy with fluor and calcium to these RC menopausal women, may be more beneficial in tenm of B~,~ ~xo,~rlng tha. it is ~.~ed in ~ ~igin~ n'm~pausal controls tn~elving the same treatmenL From the foregoing,, we are ca,"rTing out a clinical atudy in which women pertaining to the RC (casas) am compared with women living in the same area, matched for age and duration of numopanse, if present (controls).All participants fulfilled a qucsticemaire that included: a...

Experimental inflammatory arthritis (EIA) produced by carrageenan injection provokes a rapid bone remodeling state with cortical and cancellous bone loss. The objective of this study was to determine whether changes in cortical mechanical properties and/or geometry occur in long bones, either near or remote to the site of inflammation. EIA was induced in the right tibio-femoral joint of rabbits over 56 days. The right humerus and right femur from 15 normal and 25 arthritis group animals were excized. Semi-cylindrical specimens of the medial cortical shaft were subjected to non-destructive four-point bending tests. Transverse sections at the four contact sites of the loading jig were photographed and digitized to obtain average cross-sectional area (A) and moment of inertia (I). Moment of inertia and slope of the load/deflection curve permitted calculation of modulus of elasticity (E) for each specimen. Load/time curves were also used to calculate per cent stress remaining in relaxation experiments. Per cent stress remaining, E, A, I and square root of I/A (radius of gyration) were examined for differences by bone (humerus, femur) and by treatment (N,A) using two way ANOVA. The induction of inflammatory arthritis did not significantly alter the modulus of elasticity in either the femur or humerus; however, arthritis reduced the moment of inertia from 34.54 +/- 2.88 x 10(-12) m4 to 25.06+/-1.80 x 10(-12) m4 (mean+/-SEM, p < 0.05). This was observed in the femur (near the arthritic joint), but not in the humerus (remote from arthritic joint). Analysis of area and ratio I/A demonstrated that this geometric effect of treatment was due to reduced area without gross cross-sectional shape changes. Per cent stress remaining in the femur (but not in the humerus) was higher in the arthritis specimens than in the normal specimens (N: 80.86 < 0.97%; A: 83.25 +/- 0.71%, p < 0.05). Thus, in this arthritis model, the principal mechanical or geometric effect on cortical bone was reduction of the cross-sectional area and moment of inertia. The viscoelastic relaxation response of bone was also altered, perhaps due to loss of water or collagen degradation.