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This report provides a brief summary of information presented at a workshop on regenerative medicine held in Kobe, Japan, on October 20-22, 2004. A major focus of the workshop was the identification and characterization of adult and embryonic stem cells, including approaches to manipulate these-in terms both of maintaining stemness and of driving differentiation toward a desired phenotype-and current developments toward their therapeutic use in regenerative medicine. Stem Cells 2005;23:707-709