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A289 SAPIEN ® transcatheter implantation therapy versus drug treatment with or without aortic balloon valvoplasty. The outcomes used were effectiveness (as measured by clinical outcomes chance of successful implantation procedure and survival) and safety. The results were expressed as the reason of incremental cost-effectiveness ratio (ICER) per years saved and years free from serious adverse events. Probabilistic sensitivity analysis was performed on the main parameters of the model. RESULTS: Compared with medical therapy with or without aortic balloon valvuloplasty, the employment of the SAPIEN ® valve presents safety in the procedure, increased survival and compatible ICER-US$ 40.000/life of year saved. CONCLUSIONS: The use of SAPIEN ® transcatheter implantation results in improved survival and functional improvement in patients with low risk of serious adverse events, and demonstrates a costeffectiveness profile when compared to other technologies already incorporated by the Brazilian public health system.

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