This study was done to compare the efficacy of post-operative analgesia of epidural Fentanyl and buprenorphine along with bupivacaine in gynaecological surgeries. MATERIALS AND METHODS: 60 female patients posted for elective gynaecological surgeries were selected. They were randomly divided into 2 groups of 30 patients each. Group A received Fentanyl citrate 2mcg/kg with 10ml 0.125% Bupivacaine and Group B received Buprenorphine hydrochloride 3mcg/kg with 10ml 0.125% Bupivacaine epidurally post operatively. The parameters recorded were HR, RR, MAP, VAS, Wt of patient, OOA (onset of analgesia) and DOA (duration of analgesia). RESULTS: The significance was calculated using T test. The results showed that 0.125% bupivacaine and buprenorphine was better than 0.125% Bupivacaine with Fentanyl. CONCLUSION: Addition of buprenorphine to bupivacaine by epidural injection for post-operative analgesia improves the onset, the duration and the quality of analgesia, albeit keeping the possibility of late respiratory depression.