Diagnostic utility of HE4 was similar to that of NSE and ProGRP. Complementary to NSE, determination of HE4 seems to be helpful in evaluation of SCLC patients' prognosis.

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Aim of the studyWe aimed to assess the alterations of serum C-reactive protein (CRP) and albumin levels in colorectal cancer patients who underwent preoperative radio(chemo)therapy and those who did not.Material and methodsThe determinations of albumin and CRP were performed before and at 2, 3, 5 and 7 days after surgery in 60 colorectal cancer patients. 25 healthy subjects served as a reference group. For each patient the modified Glasgow Prognostic Score (mGPS) was calculated.ResultsOn the operation day CRP and albumin concentrations were not different in preoperatively treated or radiotherapy naïve patients. On postoperative day 2, 3, 5 and 7 no significant differences were observed between the two groups, with the only exception for albumin concentration, which was significantly higher on postoperative days 2 and 7 in the radiation naïve group. In all patients perioperative alterations of serum CRP level were significant at all time points (preoperatively vs. day 2, day 2 vs. day 3, day 3 vs. day 5, day 5 vs. day 7). The albumin decrease from the preoperative day to postoperative day 2 was significant, as was its increase from postoperative day 3 to 5.ConclusionsWe have seen no differences in the CRP and albumin concentrations in preoperatively irradiated versus non-irradiated colorectal cancer patients on the day of surgery and on postoperative days 2, 3, 5 and 7. There were, however, significant concentration changes in the value of these two serum markers from preoperatively to postoperative day 2 and over the following postoperative week, but presumably related to the surgical trauma, not the neoadjuvant treatment.

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ntroduction: Squamous cell carcinoma antigen isolated by Kato and Torigoe in 1977, belonging to the serine and cysteine proteases inhibitors has been recognized as the marker of choice for the cervical cancer. However, high SCC expression has been also found in others neoplasms such as non-small cell lung cancer and head and neck carcinoma.<br>Material and Methods: For many years, for serum SCC-Ag determination the chemiluminescent microparticle immunoassay with the reference standard from Abbott Diagnostics has been used. Recently, also the electrochemiluminescence immunoassay produced by Roche Diagnostics is applied. This method has been standardized against the ARCHITECT SCC assay from Abbott Diagnostics.<br>Results: Significant correlations between the results of both analyzed tests were shown. The concentration of squamous cell antigen was tested using the ARCHITRCT SCC and COBAS SCC test in 109 patients with cervical cancer. The comparative analyses have revealed the higher COBAS SCC results in comparison with the ARCHITECT SCC assay across the all concentration range. The results obtained with the new COBAS SCC test were significantly higher than the previously used ARCHITECT SCC test.<br>Comments: The significant differences between SCC-Ag concentration of COBAS SCC and ARCHITECT SCC may be due to the different SCCA1 and SCCA2 properties of monoclonal antibodies.