In the human placenta, besides the fetal blood vessel system a second extravascular contractile system exists. It is localized in the chorionic plate and runs in a longitudinal direction and adjacent to fetal blood vessels into the stem villi, where it forms perivascular contractile sheaths. Characteristically, cells of the extravascular contractile system are extremely long and spindle-shaped and give rise to fine cell processes, by which they obviously contact each other or insert into the basement membrane of the trophoblast. They show immunoreactivity with desmin, vimentin, alpha-actin, myosin, nitric oxide synthase type I (brain form) and dipeptidyl peptidase IV. The ultrastructure suggests that cells of the extravascular contractile system are related to smooth muscle cells, including subpopulations with myofibroblastic features. In stem villi a few cells are nitric oxide synthase type I immunoreactive. These cells are thought to be specialized smooth-muscle-like cells of the extravascular contractile system or cells of the extravascular contractile system related to paraneurons that generate nitric oxide, which, in turn, may modulate the tone of perivascular contractile sheaths. The high dipeptidyl peptidase IV activity suggests that modulation of the extravascular contractile system may also occur by substance P.

In den letzten ffahren erschienen des Oefteren Mittheflungen tiber das Vorfinden yon Streptotricheen bei Menschen and Thieren. Das eingehendere Studium dieser Mikroorganismen hat ergeben, dass sie zweifellos als pathogene Erreger zu betraehten sind.Horst (1)

gew. Externarzt an der dermatologischen Klinik des Prof. Pick, jetzt klin. Assistent am Kaiser Franz 5oseph-Kinderspitale in Prag. ~. Der Verlauf des Bienenstiehes beim normalen und bienengiftfesten Mensehen.

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