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In our study, we identified that paternal occupational exposure, first-trimester maternal illness, first-trimester maternal bad mood, first-trimester maternal diet of eggs or milk (≥5 meals per week), and first-trimester maternal sexual activities were significantly associated with increased CL/P.

By precisely writing down the matrix element of the local Boltzmann operator ($${\mathrm{e}}^{-\tau h}$$ e - τ h , where $$h$$ h is the Hermitian conjugate pairs of off-diagonal operators), we have proposed a new path integral formulation for quantum field theory and developed a corresponding Monte Carlo algorithm. With the current formula, the Hubbard–Stratonovich transformation is not necessary, accordingly the determinant calculation is not needed, which can improve the computational efficiency. The results show that, the simulation time has the square-law scaling with system sizes, which is comparable with the usual first-principles calculations. The current formula also improves the accuracy of the Suzuki–Trotter decomposition. As an example, we have studied the one-dimensional half-filled Hubbard model at finite temperature. The obtained results are in excellent agreement with the known solutions. The new formula and Monte Carlo algorithm could be applied to various studies in future.

Abstract. An amperometric electrode based on multiwall carbon nanotubes (MWCNTs) and Fe nanoparticles (NPs) has been successfully fabricated. Combined with Flow Injection Analysis (FIA) and chromatography separation column, the electrode exhibits linear response in the concentration range of 0.1 -12 μM and the sensitivity of 30.0 nA μM −1 for most of amino acids. The determination of 17 amino acids in the hypothalamus microdialysis fluids of guinea pigs, illustrates that the electrode is a powerful tool to investigate physiology and pathology mechanisms