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Introduction. Despite the large number of analgesic drugs available currently, pain therapy is still a challenging issue for researchers and clinicians. The search for new drugs that could relieve patients from pain is not only justified, but also highly recommended. Objective.This study aimed to perform antinociceptive screening of 4 various 1,2,4-triazole-3-thione derivatives (TPB-2, TPB-4, TPF-32 and TPF-38) in the hot-plate test in mice, which is an experimental model allowing the testing of compounds alleviating acute thermal pain. Materials and method. Experimental verification of the antinociceptive effects of the tested compounds (administered intraperitoneally in a constant dose of 300 mg/kg) was performed in the hot-plate test in mice, by calculating maximum possible antinociceptive effects (MPAE in %) at 4 various pretreatment times (15, 30, 60 and 120 min.). Results. TPB-2 exerted strong antinociceptive effects with MPAE ranging between 18.54-35.43% in the hot-plate test. Similarly, TPF-32 exerted firmly established antinociceptive effects with MPAE ranging from 13.50-37.05%. In the case of TPB-4 and TPF-38, both compounds produced slight changes in MPAE in the hot-plate test in mice. These agents can be classified as virtually ineffective in the hot-plate test. Conclusions. The screening test revealed that TPB-2 and TPF-32 exerted a clear-cut antinociceptive effect in the hot-plate test in mice. If the results from this study were to be translated to clinical settings, both TPB-2 and TPF-32 might be beneficial drugs for pain relief in humans.

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