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In search of a specific diagnostic serological test in cancer we have looked for a high degree of positive results in known cancer cases and a high degree of negative results in non-cancerous disease. Dunn and Greenhouse (1951) tentatively set limits of 90% accuracy in cases of cancer and 95% accuracy for patients with non-cancerous disease. Makari (1955) described the use of the Schultz-Dale test for the detection of carcinoma antigen in the serum of patients with carcinoma. It was shown that, when the carcinoma antigen used for immunization of guinea-pigs was the sediment obtained between 3,200 and 4,000 r.p.m., this test would conform to the criteria set up by Dunn and Greenhouse-that is, it was positive in 96.8% of proved carcinoma cases and negative in 95.2% of non-cancerous lesions. Recently Burrows (1958) was able to confirm our results in a large series of 508 patients, and recorded an accuracy of 96.7% in proved carcinoma cases and of 96.7% in non-cancerous lesions. This establishes the

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