Use of Schultz--Dale Test for Detection of Specific Antigen in Sera of Patients with Carcinoma

Makari, Jack G.

doi:10.1136/bmj.2.4951.1291

Cited by 55 publications

(26 citation statements)

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“…Since then antigen-induced contraction of smooth musetes in vitro has become a standard 9 technique for demonstrating anaphylactic hypersensitivity and is commonly known as the 'Schultz-Dale phenomenon' [3][4][5][6]. Subsequently, Schultz-Dale anaphylactic contractions have been demonstrated in guinea-pig ileum , duodenum [8], uterus [7,9,17,18,20,23,32,34,40,[52][53][54][55][56][57][58][59], trachea [37,49,[60][61][62][63][64], oesophagus [9,65], taenia-coli [6,66,67] and seminal vesicles [9,24]; rat uterus [34,[68][69][70], colon [70] and ileum [34]; rabbit pulmonary artery [71], intestine [72] and bronchioles [73]; mouse uterus [74,75]; human bronchus [76]<...>…”

Section: Introductionmentioning

confidence: 99%

The Schultz-Dale reaction: A review

Chand

Eyre

1978

Agents and Actions

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Vascular (pulmonary and hepatic blood vessels) and nonvascular (gastro-intestinal, reproductive and respiratory systems) smooth muscle preparations obtained from specifically sensitized animals of numerous species including man contract to specific antigen in vitro (Schultz-Dale phenomenon). This immunopharmacological technique is a useful tool to demonstrate immediate-type hypersensitivity in actively or passively sensitized tissues and may be used to investigate the nature of the principal pharmacological mediators involved in a particular tissue as well as to screen anti-anaphylactic (anti-allergic) drugs. However, much remains to be investigated on the complex mechanisms of action of antigen, desensitization and resensitization (recovery) of anaphylactic responsiveness.

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Section: Introductionmentioning

confidence: 99%

The Schultz-Dale reaction: A review

Chand

Eyre

1978

Agents and Actions

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“…Ayre, Lewis, Ressel, and Le G uerrier This paper was presented in part at the Annual Meeting of the National Institute of Science, Virginia State College, Petersburg, Va., April 1-3, 1971, and at the 80th Annual Meeting of the Ohio Academy of Science, Akron, Ohio, April 22-24, 1971. to produce cancer sera for passive immunization and vaccines for active immunization' [I], Brilliant inroads have been made by such men as Zilber, who investigated tumor antigens to induce in vivo anaphylaxis [2]; and Makare [3,4], Burrows [5], G race and Lehoczky [6] who demonstrated a tumor-specific factor in their studies of the Schultz-Dale test. This was followed by DeCarvalho's intriguing report of isolating a tumor-specific factor, its use in inducing antitumor antibodies in horses, and the subsequent use of those antibodies in passive immunologic cancer therapy [7], More recently Finney et al [8] and Czajkowski et al [9] reported extremely encouraging results in their separate attempts to induce active immunity by autoimmunization.…”

Section: Introductionmentioning

confidence: 99%

Effects of a Coupled Tumor Protein Antigen (Lewis CTPA) on the Growth of Transplanted Tumors in Inbred Mice

Phillip¹,

Lewis²,

Daily³

1971

Oncology

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Small pieces, approximately 2 mm³, of a single, spontaneous adenocarcinoma excised from a retired breeder C₃H/HeJ mouse, were implanted in the left side of the axillary fold of 125 thirteen-week-old male and female C₃H/HeJ mice. The mice were then given weekly injections of a coupled tumor protein antigen which was prepared by extracting the antigen from spontaneous mouse tumors and coupling the antigen with human γ-globulin using bis-diazotized benzidine. Careful weekly examinations for 6 weeks after the initial implantation revealed major differences intumor sizes between the treated and untreated mice.

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“…Rather little has been said about cancer Makari, 1955;Tee & Munson, 1977Lewis Test Lewis et al, 1966T Globulin Tal & Halperin, 1970Herberman, 1977 (Field & Caspary, 1970) and the Structuredness of Cytoplasmic Matrix or SCM Test (Cercek & Cercek, 1977). Both of these tests were based on sensitisation of the cancer patients' lymphocytes to myelin basic protein or a closely related substance and their proponents cooperated with others who later became involved in further evaluation.…”

Section: Cancer Testsmentioning

confidence: 99%

Third Gordon Hamilton-Fairley Memorial Lecture. Tumour markers—Where do we go from here?

Bagshawe¹

1983

Br J Cancer

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An overview of the application of markers for solid tumours is presented. Some of the potential problems with general cancer tests are considered as well as the ways in which the more specific markers have been applied. The limited specificities of markers defined so far remain a serious limitation but they have found useful clinical application. Their use in radioimmunolocalisation provides an interesting challenge to the physical methods of tumour localisation and the possibilities of drug targeting by antibodies are as exciting as the difficulties are formidable. It is, I suggest, a field that will continue to evolve and be productive.

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Use of Schultz--Dale Test for Detection of Specific Antigen in Sera of Patients with Carcinoma

Cited by 55 publications

References 1 publication

The Schultz-Dale reaction: A review

The Schultz-Dale reaction: A review

Effects of a Coupled Tumor Protein Antigen (Lewis CTPA) on the Growth of Transplanted Tumors in Inbred Mice

Third Gordon Hamilton-Fairley Memorial Lecture. Tumour markers—Where do we go from here?

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