Purpose The purpose of this paper is to provide a contextual analysis that helps explain how socio-cultural factors are negatively impacting the evolution of the entrepreneurial ecosystem in a struggling regional economy. Design/methodology/approach A case study method is used to provide a detailed contextual analysis triangulating primary and secondary data. Findings This paper provides insight into a region impeded from embracing the benefits of innovation-driven entrepreneurship in fostering economic development. The authors show that socio-cultural factors may be inhibiting the region from having a functional entrepreneurial ecosystem that can support innovation. Specific aspects of culture and social capital weaknesses are identified and insight into the potential causes of these impediments were offered. As well, the paper shows how the fundamental nature of culture may be affecting other elements of the entrepreneurial ecosystem from maturing. Originality/value This paper adds to a small, but growing, body of literature that is illustrating the evolutionary nature of entrepreneurial ecosystems and the significant impact of socio-cultural attributes to that evolution. This paper responds to calls to investigate contexts in which innovation does not thrive and where economic challenges prevail. The value of this research paper is to provide conceptual contributions in a contextual analysis from which other researchers can draw comparisons, insights and inspiration for similar approaches. Despite the abundance of research discussing the importance of culture, there are very few actual case studies showing concrete examples of culture and its influence on a region’s entrepreneurial ecosystem.

BackgroundElastomeric pumps are often used to administer intravenous antibiotics in the outpatient setting, but effective infusion requires that the drug remain stable in solution throughout the procedure.ObjectiveTo determine the chemical stability of ceftolozane/tazobactam when reconstituted and stored over an extended time in the AccuFlo (EMED Technologies, El Dorado Hills, California) and I-Flow Homepump Eclipse (Halyard, Alpharetta, Georgia) elastomeric pumps compared with the results of the label-supporting studies in polyvinylchloride (PVC) bags.MethodsTwo ceftolozane/tazobactam dosages were tested for the elastomeric pump studies: 1500 mg (1 g ceftolozane/0.5 g tazobactam) and 150 mg (100 mg ceftolozane/50 mg tazobactam). The solution hold time was evaluated for 10 days at 5°C (±3°C) (tolerance ±3 hours) and for 1 day (24 hours) at ambient room temperature (tolerance ±3 hours). Results of a previously conducted label-supporting PVC intravenous bag study were used as a comparator.ResultsAt each time point, the visual appearance of all pump and PVC bag solutions remained clear and free of visible particulates, and subvisible particulate matter did not differ significantly between the initial time point and at 10 days. No notable changes in pH in any of the pump or PVC solutions occurred throughout the study. Recovery of ceftolozane and tazobactam was greater than 93% and 94%, respectively, for all samples (elastomeric pump and PVC bag) at 10 days.ConclusionsCeftolozane/tazobactam remains physically and chemically stable for at least 7 days, as indicated on the US label, when reconstituted, diluted, and stored in the AccuFlo and I-Flow Homepump Eclipse elastomeric pumps and in PVC intravenous bags.

In this paper, we provide insights for knowledge mobilization and university-community engagement based on the lessons learned from the Advancing Innovation in Newfoundland and Labrador Project. Out hope is to provide a window into the experiences of academics as they navigate the complexities and politics of mobilizing research and engaging with diverse stakeholders. Despite the challenges of this work, presented by factors inside and outside the academy, it is crucial to enhance our capabilities if we are to maximize the impact of universities in linking theory, research, and expertise with critical social and economic needs, such as enhancing innovation.

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