In the area of heterocyclic chemistry, oxadiazole has made major contributions. An enormous number of oxadiazoles have been synthesized and exposed to biological screening; the screening results improved their status due to its potential activities and their efficacy in diverse fields of daily life. Due to its wide range of pharmacological and therapeutic effects, the 1,3,4-oxadiazole moiety is the most important oxadiazole. In this study, we discuss a new family of 2,5-disubstituted 1,3,4-oxadiazole compounds' anti-inflammatory characteristics (4a-4h).The antiinflammatory efficacy of the oxadiazole derivative was studied by utilizing Human Red Blood Cell membrane stabilization (HRBCs) method. Many synthesized compounds displayed remarkable anti-inflammatory activity in HRBCs test. In the novel synthesized derivatives, compounds 2-(5-bromo-2-(trifluoromethoxy)phenyl)-5-p-tolyl1,3,4-oxadiazole (4h) and 2-(5-bromo-2-(trifluoromethoxy) phenyl)-5-phenyl-1,3,4-oxadiazole (4a) exhibited the maximum activity of 90.76 % and 88.35 % protection, respectively at concentration 500 µg/ml, compared with DFS that showed 91.86 % inhibition of RBC haemolysis at the same concentration.

This study was performed to examine molecular docking of newly synthesised thiazolidinone compounds and discover potential InhA inhibitors. MIC screening produced thiazolidinone derivatives for Staphylococcus aureus illness. KBr pellet FT-IR spectra were collected on a Thermo Nicolet AVATAR-330 spectrometer. Bruker obtained 400 MHz 1H spectra of all chemicals in DMSO-d6. Five 4 thiazolidinone derivatives:4-(4-oxo-2-phenylthiazolidin-3yl)amino)benzyl)oxazolidin-2-one(8), ((2-(4 chlorophenyl)-4oxothiazolidin-3yl)amino)benzyl)- oxazolidin-2-one(9), ((2-(4-fluorophenyl)-4-oxothiazolidin-3 yl)amino)benzyl)oxazolidin-2-one(10), 4-(4-((4-oxo2-(p-tolyl)thiazolidin-3yl)amino)benzyl)oxazolidin-2-one(11) and 4-(4-((2-(4 methoxyphenyl)-4-oxothiazolidin3yl)amino)benzyl)oxazolidin-2-one(12) docked due to its vast biological usefulness. Molecular docking, ADMET, TOPKAT Toxicity, and molecular dynamic simulation were used to estimate drug-likeness for 1QG6. MIC screening of synthesised thiazolidinone derivatives against Staphylococcus aureus through disc diffusion. Molecular docking studies examining the inhibitory effect of produced substances suggest testing for MIC antibacterial activity. Compound 12's antibacterial activity against Staphylococcus aureus is compared to Ampicillin and Cefixime. Compound 12 is utilised as an alternate medication for Staphylococcus aureus