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The concept of flag species has driven conservation projects for 50 years. Five species native to San Andrés Island are here proposed as flag species for conservation of the few mangrove remnants on the island: Bontia daphnoides (Myoporaceae), Canella winterana (Canellaceae), Eustoma exaltatum (Gentianaceae), Rhabdadenia biflora (Apocynaceae), and Selenicereus grandiflorus (Cactaceae). Four of these species are documented here for the first time for the Flora of the Archipelago; three of them represent the first reports for the Flora of Colombia, two of which are at the family level (Canellaceae and Myoporaceae).