Introduction andOjective. The skin is the most important external organ, protecting against pathogens, physical and chemical injuries, as well as ultraviolat (UV) radiation. Continuous exposure to UV radiation, allergens, and pollutants, as well as consumption of highly processed foods, all promote the development and exacerbation of skin diseases, which appear highly differentiated. Skin diseases have a significant impact on the patient's quality of life and psychological well-being, which is why finding effective therapeutic compounds appears to be so important, especially since multiple conditions still remain untreated. The benefits of flavonoids in the management of psoriasis, acne, atopic dermatitis, urticaria, ringworm, and other skin diseases, are discussed in this review. Review methods. A search was conducted using PubMed and Google Scholar databases for articles, to assess the effect of flavonoids in the prevention and treatment of skin diseases. Articles in both Polish and English were searched for. To eliminate duplicate works, the bibliography was reviewed. Brief description of the state of knowledge. Flavonoids' antioxidant and photoprotective properties are the primary factors influencing their preventive use in the development of skin diseases. The risk of tumour formation is significantly reduced as a result of these two applications. They hasten the healing of long-lasting wounds and ulcers due to their circulation-stimulating properties. Plants high in flavonoids are used in dressings and poultices. Their extracts are used in creams and solutions to treat and prevent a variety of skin diseases. Summary. The antioxidant and anti-inflammatory effects of flavonoids makes them an important reference in the treatment of skin diseases. The advancement of natural medicinal substances is a critical aspect of modern medicine.

Introduction andObjective. Known for their strong antioxidant properties, flavonoids are the major polyphenolic compounds found in a wide variety of plants, vegetables, and fruits. A growing number of reports has indicated their anticancer effect. Affecting numerous cellular pathways, polyphenols suppress carcinogenesis which allows for new strategies developed to fight skin cancer. Given the high morbidity and mortality rates due to skin cancer, the aim of the review is to summarize earlier studies on the role of flavonoids in skin cancer prevention and treatment. Review Methods. A search was conducted using the PubMed databases. Using keywords related to flavonoids and skin cancer, articles in Polish and English were manually searched. Duplicate papers were removed, and the bibliographies of selected studies as well as bibliographies from other reviews were reviewed in order to incorporate additional relevant studies into the review. Brief description of the state of knowledge. Flavonoids are effective immunomodulators since they modulate cell growth, induce apoptosis, and reduce reactive oxygen species production. They have DNA repair abilities that can be used to prevent various skin diseases caused by excessive sun exposure. They can prevent, postpone, or completely stop photocarcinogenesis. Summary. Because of their effect on numerous cellular pathways, flavonoids have been studied extensively to confirm their preventive and therapeutic potential in skin cancer. Flavonoids have been shown in studies to shrink cancerous tumours and prevent metastasis. Their use in prevention and anticancer therapies may contribute to lower skin cancer mortality rates.

Introduction and Objective.Periodontal disease is one of the many diseases of the oral cavit. Periodontium is defined as the tissues that surround and hold the tooth in the socket. Periodontitis may lead to the loss of hard and soft tissues, resulting in the loss of dentition. The current standards for the treatment of periodontal disease are based on both surgical treatment and non-surgical treatment. The subject of research among many scientists is the effect of flavonoids -substances of plant origin, on periodontal diseases. This literature review aims to present the possibility of using flavonoids as adjunctive treatment in periodontal diseases. Review Methods. Articles in English were searched using PubMed databases to evaluate the effect of flavonoids in the prevention and treatment of periodontal disease. The bibliography was reviewed to eliminate duplicate works. Brief description of the state of knowledge. The anti-inflammatory, antibacterial and antiresorptive properties of flavonoids are the main factors influencing their use in the prevention of periodontal disease. Thanks to these three properties, the risk of periodontal disease is significantly reduced, which is why extracts from plants with a high flavonoid content are increasingly used in products for daily oral hygiene. Summary. The antibacterial, anti-inflammatory and antiresorptive effects of flavonoids make them an important factor in the treatment of periodontal disease. Further research in the use of natural medicinal substances of plant origin is an important aspect for the development of modern medicine.