Introduction: Naproxen is a non-steroidal anti-inflammatory drug mainly used to treatinflammation, pain, and fever of various etiology. Scientific studies conducted over the lastfive years have shown, that its introduction significantly influenced neoplastic processes inthe in vitro and in vivo studies carried out within cell cultures and animal models.Aim of the study: Our aim was to review the theses, extract and present the influence ofnaproxen and its derivatives in signaling pathways involved in the initiation, promotion andprogression of cancer as well as to indicate potential directions for further research.Methods and materials: We have reviewed the theses in the bibliographic PubMed database,using the keywords: „naproxen”; „naproxen derivatives”; „cancer”; „cancer treatment”„cancer prevention”.Results: In addition to the well-known mechanism of inhibiting COX, there are scientificproofs of the activity of naproxen against other molecules, such as PI3-K(phosphatidylinositol 3-kinase), GSK-3β (glycogen synthase kinase-3β), NFκB (nucleartranscription factor κB), MMP ( metalloproteinases), NO (nitric oxide) involved in neoplasticprocesses.Conclusion: Conclusions drawn from the analysis of specific molecular activities of naproxenand its derivatives against neoplastic processes are promising. However, more preclinicalresearch is needed to confirm the effectiveness, practical applicability and to assess the sideeffects of the therapy, before starting the clinical trials in humans.

Introduction: Contrast-induced nephropathy is one of the most serious adverse effects of radiocontrast agents usage. It is currently listed in the literature as the third most common cause of iatrogenic acute kidney injury. Aim of the study: The aim of this study is to provide an overview of the extent, severity and prevention of CIN. It is to shed a broader light on this disease entity and be a helpful resource in the future for other clinicians struggling with CIN. Methods and materials: A literature review was conducted using the PubMed database, using the keywords: "contrast-induced nephropathy"; "acute kidney injury"; "contrast media". Results: Pathogenesis of CIN is not entirely clear. There are many risk factors being e.g. diabetes, chronic kidney disease, advanced age (patients over 75 years old). Prevention methods include restricting contrast volume to a minimum, balancing the patient's volaemia before contrast administration or perioperative saline hydration to normalise volaemia. Conclusion: CIN is a significant health problem, which can be a life threat. Despite the fact that the exact pathogenesis of the condition still remains unknown, the CIN prophylaxis becomes more and more effective due to better recognition of risk factors and the usage of adequate prevention measures appropriate to the patients' condition. More studies, with larger test groups, are needed to better define both the pathomechanism of contrast-induced acute kidney injury and new, more effective ways of prevention and treatment of this condition.

Introduction: Cardiovascular diseases (CVDs) remain major problem in modern medicine. According to World Health Organization they are the leading cause of death. Despite increased awareness about impact of healthy lifestyle,  mortality still remains on high level. Cardiovascular diseases requires multidisciplinary treatment. One of those aspects is determinate an appropriate diet.   Purpose: The aim of this systemic review is to collect, evaluate and summarize the information on fasting mimicking diets and it is effect on therapy and prevention in cardiovascular diseases. Material and methods: Analysis and review of available literature. The search of articles in popular scientific databases such as PubMed, Google Schoolar WHO database State of knowledge: Risky behavior include unhealthy diet, tobacco use, physical inactivity, alcohol abuse. Those behaves lead obesity, raised blood pressure, hyperglycemia, dyslipidemia. Those factors have significant impact on the increase of cardiovascular diseases in the population. Fasting and calorie restriction are becoming more and more popular. Results: Many studies indicate that fasting mimicking diet can prevent from excessive fat accumulation, obesity, diabetes, dyslipidemia, hypertension As a result it decreases probability of cardiovascular diseases. Those diets not only support weight loss, but also can help maintain good health  and extend lifespan.

Introduction: The Covid-19 pandemic and the increase in monkeypox (Mpox) infections that have been with us for the past two years have forced scientists and doctors to intensify their efforts to understand them. They mainly affect the respiratory, circulatory and immune systems and cause skin lesions. They can lead to death from lung disease, so complications such as ophthalmic ones are not often described in scientific studies, but doctors report that Covid-19 and Mpox patients not infrequently show symptoms such as inflammation, conjunctival congestion, corneal ulceration, swelling of the eye area and others. Aim of the study: The aim of this study was to review scientific articles with a view to presenting the problem of ocular complications following SARS-CoV-2 infection and ways to prevent them. Methods and materials: a literature review was conducted using the PubMed database, using the keywords: “ocular complications”, “ophthalmic complications” “ocular manifestations”, “eye complications”, “monkeypox”, “Mpox”, “Covid-19” “SARS-CoV-2”. Results: PCR studies from conjunctival swabs have confirmed the presence of SARS-COV-2 and MPXV genetic materials in ocular secretions, so they are a reservoir of viruses and pose a risk of further transmission. In the case of Covid-19, the eye can act as a host for infection. Humidification and preventive antibiotic therapy have been shown to prevent bacterial superinfection and avoid serious ocular complications, including loss of vision. Conclusions: Patients with Covid-19 and Mpox should be diagnosed ophthalmologically, as neglect can lead to deterioration and even loss of vision, reducing their quality of life. Eye care treatments and pharmacotherapy prevent future complications. It is also important to use personal protective equipment, take care of hygiene and disinfect equipment used for ophthalmic examinations to prevent the spread of infections to other patients as well as to medical staff.