Long-term forecasting of socio-economic processes is the basis for ensuring regional security. In a crisis, the mechanisms of a market economy are always aimed at constant reforming of economic science in order to ensure the ecological balance and responsible resource consumption. The foresight method as a long-term forecasting, carried out to build routes for future development, is becoming one of the most relevant in developed market economies countries. Foresight of the future and the application of methods for changing it at the world, macro and micro levels determine the search for solutions by the authorities in the development of socio-economic policy that does not violate the ecological balance. It is clear that the constant change of paradigms in the ecological and socio-economic course of the real life of society significantly complicates the foresight processes at the macro and micro levels, causing the transformation of already established plans, programs, projects of environmental and socio-economic policy. The economic crisis at the beginning of 21st century, which lasts for the second decade, was complicated by the conditions of a pandemic, the forced measures of which are to slow down the processes of production and consumption. At present, using of foresight system is aimed at achieving achievements that are subordinate to national goals, which it is advisable to confirm with the apparatus of mathematical models and system analysis in substantiating the methodological foundations of the ecological balance.