BRITISH MEDICAL JOURNAL VOLUmE 290 23 MARCH 1985 895 of the cups was not standardised and the intake of coffee was not graded within each subject. Even so, the conclusion from this experiment must be that abstention from coffee in hypercholesterolaemic men is followed by a substantial reduction in total cholesterol concentration. The implication of this relation is not clear yet, but the reduction in total cholesterol concentration in the present subjects was comparable with that observed in the Oslo study in which the traditional low fat, low cholesterol diet was used and a considerable reduction in coronary morbidity and mortality was observed.5 On the basis of these and our earlier findings we thought it safe to advise hypercholesterolaemic subjects in our population to reduce their coffee consumption. We are, however, reluctant to advise people generally to do this because of the lack of prospective data and the possibility of singling out and eliminating the active substance from coffee.

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