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Structured Abstract Background COVID-related misinformation is prevalent online, including on social media. The purpose of this study was to explore factors associated with user engagement with COVID-related misinformation on the social media platform, TikTok. Methods A sample of TikTok videos associated with the hashtag #coronavirus were downloaded on September 20, 2020. Misinformation was evaluated on a scale (low, medium, high) using a codebook developed by experts in infectious diseases. Multivariable modeling was used to evaluate factors associated with number of views and presence of user comments indicating intention to change behavior. Results 166 TikTok videos were identified and reviewed. Moderate misinformation was present in 36 (22%) videos viewed a median of 6.8 million times (interquartile range, 3.6—16 million), and high-level misinformation was present in 11 (7%) videos viewed a median of 9.4 million times (interquartile range, 5.1—18 million). After controlling for characteristics and content, videos containing moderate misinformation were less likely to generate a user response indicating intended behavior change. By contrast, videos containing high-level misinformation were less likely to be viewed but demonstrated a non-significant trend towards higher engagement among viewers. Conclusions COVID-related misinformation is less frequently viewed on Tiktok but more likely to engage viewers. Public health authorities can combat misinformation on social media by posting informative content of their own. Lay Summary COVID-related misinformation is prevalent online, including on social media. The purpose of this study was to explore factors associated with user engagement with COVID-related misinformation on the social media platform, TikTok. We reviewed a sample of 166 TikTok videos associated with the hashtag #coronavirus posted between the beginning of the pandemic and September 2020. Misinformation was evaluated on a scale (low, medium, high) using a codebook developed by experts in infectious diseases. Moderate misinformation was present in 36 (22%) videos viewed a median of 6.8 million times, and high-level misinformation was present in 11 (7%) videos view a median of 9.4 million times. After controlling for characteristics and content, videos containing moderate misinformation were less likely to generate a user response indicating intended behavior change. By contrast, videos containing high-level misinformation were less likely to be viewed but demonstrated a trend towards higher engagement among viewers. Public health authorities can combat misinformation on social media by posting informative content of their own.

Objective This article describes a novel clinical rotation that uses technology to create a remote ophthalmology learning experience with the goal of improving virtual exposure to medical and surgical ophthalmic training for medical students. Methods Our unique curriculum incorporates mobile-mounted tablets which allow students to virtually participate in inpatient consults, clinic, and ophthalmic surgery. An adaptable mounting device attached to the slit lamp allows students to observe examinations in real time, enhancing recognition of ocular pathologies. Students participate in a robust curriculum that includes independent learning modules, video lectures, interactive modules, podcasts, and surgical video rounds. Students engage with residents and faculty in interactive-guided lectures and case-based discussions that focus on the American Academy of Ophthalmology white paper teaching objectives. Students are mailed surgical instruments and participate in surgical modules and faculty-led virtual wet laboratories. Results Our unique virtual curriculum combines didactic learning, interactive content, and novel technology applications such as mobile tablets, slit lamp-mounted devices, and faculty-led virtual wet laboratories. Conclusion Virtual technologies can be utilized to enhance ophthalmology medical student education in a safe and effective way during the coronavirus disease 2019 pandemic, and to improve educational access in the future.

The magnetic label did not affect the physiological characteristics of the cells and did not change identity, purity and potency (therapeutic effect in vivo) of EVs. MRI phantom studies confirmed the in vitro/ex vivo detectability of labeled-EVs. Importantly, as expected MRI studies showed that EV homing to the kidney injected intra-cardiacally into Alport mice was more efficient vs the retro-orbital route, and Prussian blue staining of sections confirmed EV homing to the kidney.CONCLUSIONS: We have developed a clinically applicable novel magnetic nanoparticle agent that can be used to label and track the biodistribution of EVs in the kidney and other organs using noninvasive, safe, and effective MRI technology that's widely available. This technology is highly adaptable and can be deployed in both preclinical and clinical settings.