Background: The use of tobacco may affect the human oral microbiome resulting in numerous diseases including cancer. There are more than 1.3 billion tobacco smokers worldwide with 4.5 million adult Nigerians addressed as tobacco addicts. Tobacco smoking causes oral cancer, color change on the teeth, halitosis, periodontitis and other health implications. Aim: The study was aimed at determining the changes caused by tobacco smoking on the oral microbiome of cigarette smokers and the shift toward organisms that may cause oral cancer and lung diseases. Methods: One hundred and twenty subjects made of 60 tobacco smokers and 60 nonsmokers were enrolled for the study. Oral swabs were collected from the oral cavity of the subjects using sterile swab sticks under standard aseptic methods. The specimens were subjected to microscopy and culture. Organisms were identified using standard microbiological techniques. Results: The mean age of the subjects was 26.9 ± 3.4 years, with minimum age 18.0 years. There was a higher rate of bacterial colonization 86.7% among smokers than nonsmokers (χ2 = 299.0, P = 0.0002). Most members of the oral biofilm belonged to the Enterobacteriaceae with Klebsiella pneumoniae being the most prevalent isolate among smokers while Pseudomonas aeruginosa 4 (20.0%) were the most prevalent bacterial isolates among the control subjects. Tooth decay 19 (36.5%) was the oral cavity disorder among smokers associated with the highest number of isolates, followed by halitosis 18 (34.6%) and mouth ulcer 7 (13.4%). Halitosis was mostly associated with Candida species 5 (71.4%). There was a statistically significant association between oral cavity conditions and microbial isolates among smokers (χ2 = 299.0, P = 0.002). Conclusion: Smoking may have altered bacterial acquisition and oral mucosal colonization in favor of periodontal pathogens. This study have shown that smoking predisposes to oral cavity diseases which may predispose to oral cancer or lung diseases. The campaign against smoking should therefore be intensified as this may help to improve the oral health of smokers.

BACKGROUND: Few researchers have examined the effectiveness of cognitive behavioral therapy in treating aggressive behaviors among individuals with dual diagnosis (intellectual disability and mental health conditions) due to the relatively recent interest in the field of psychopathology in intellectual disability. This study investigated the effectiveness of cognitive behavioral therapy in treating aggressive behaviors among clients with dual diagnoses in a community rehabilitation center, Ibadan, Oyo state, and the moderating effects of parenting style and socioeconomic status in the associations. MATERIALS AND METHOD: A 2 × 2 × 2 pre-test post-test factorial design was used. Parenting style and socioeconomic status at two levels each moderated the associations. A sample of 22 participants purposively selected was exposed to treatment using cognitive behavioral therapy, while the other five were exposed to placebo treatment all for 8 weeks. Data collected were analyzed using Line Chart and Analysis of Covariance (ANCOVA). RESULTS: Improvements were found in the post-treatment scores obtained on the Aggressive Scale for Youths. A reduction in the Aggressive Incidents chart was recorded for each participant in the treatment group when compared with the control group, using a line chart and Analysis of Covariance (ANCOVA). Evidence also demonstrated that parenting style (authoritarian and authoritative), F (1,14) = 0.75, P <.05, η2 =0.05), and socioeconomic status (high and low), F (1,14) = 0.01, P =0.020, η2 =.00), moderated the associations. CONCLUSION: Cognitive behavioral therapy is seen as a treatment intervention for individuals with intellectual disability co-existing with mental health manifesting aggressive behaviors in the community or other settings. This should be used to improve the client's quality of life under these conditions.