The repair of complex craniofacial bone defects is challenging and a successful result is dependent on the size of the defect, quality of the soft tissue covering the defect, and choice of reconstruction method. The objective of this study was to develop a bioactive cranial implant that could provide a permanent reconstructive solution to the patient by stimulating bone healing of the defect. In this paper the authors report on the feasibility and clinical results of using such a newly developed device for the repair of a large traumatic and therapyresistant cranial bone defect. The patient had undergone numerous attempts at repair, in which established methods had been tried without success. 273Abbreviations used in this paper: bPPi = bcalcium pyrophos phates; bTCP = btricalcium phosphate.

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