Ultra-miniaturized microendoscopes are vital for numerous biomedical applications. Such minimally invasive imagers allow for navigation into hard-to-reach regions and observation of deep brain activity in freely moving animals. Conventional solutions use distal microlenses. However, as lenses become smaller and less invasive, they develop greater aberrations and restricted fields of view. In addition, most of the imagers capable of variable focusing require mechanical actuation of the lens, increasing the distal complexity and weight. Here, we demonstrate a distal lens-free approach to microendoscopy enabled by computational image recovery. Our approach is entirely actuation free and uses a single pseudorandom spatial mask at the distal end of a multicore fiber. Experimentally, this lensless approach increases the space-bandwidth product, i.e., field of view divided by resolution, by threefold over a best-case lens-based system. In addition, the microendoscope demonstrates color resolved imaging and refocusing to 11 distinct depth planes from a single camera frame without any actuated parts.

We demonstrate an imaging system employing continuous high-rate photonically-enabled compressed sensing (CHiRP-CS) to enable efficient microscopic imaging of rapidly moving objects with only a few percent of the samples traditionally required for Nyquist sampling. Ultrahigh-rate spectral shaping is achieved through chirp processing of broadband laser pulses and permits ultrafast structured illumination of the object flow. Image reconstructions of high-speed microscopic flows are demonstrated at effective rates up to 39.6 Gigapixel/sec from a 720-MHz sampling rate.

The hallmark of the information age is the ease with which information is stored, accessed, and shared throughout the globe. This is enabled, in large part, by the simplicity of duplicating digital information without error. Unfortunately, an ever-growing consequence is the global threat to security and privacy enabled by our digital reliance. Specifically, modern secure communications and authentication suffer from formidable threats arising from the potential for copying of secret keys stored in digital media. With relatively little transfer of information, an attacker can impersonate a legitimate user, publish malicious software that is automatically accepted as safe by millions of computers, or eavesdrop on countless digital exchanges. To address this vulnerability, a new class of cryptographic devices known as physical unclonable functions (PUFs) are being developed. PUFs are modern realizations of an ancient concept, the physical key, and offer an attractive alternative for digital key storage. A user derives a digital key from the PUF’s physical behavior, which is sensitive to physical idiosyncrasies that are beyond fabrication tolerances. Thus, unlike conventional physical keys, a PUF cannot be duplicated and only the holder can extract the digital key. However, emerging machine learning (ML) methods are remarkably adept at learning behavior via training, and if such algorithms can learn to emulate a PUF, then the security is compromised. Unfortunately, such attacks are highly successful against conventional electronic PUFs. Here, we investigate ML attacks against a nonlinear silicon photonic PUF, a novel design that leverages nonlinear optical interactions in chaotic silicon microcavities. First, we investigate these devices’ resistance to cloning during fabrication and demonstrate their use as a source of large volumes of cryptographic key material. Next, we demonstrate that silicon photonic PUFs exhibit resistance to state-of-the-art ML attacks due to their nonlinearity and finally validate this resistance in an encryption scenario.

A single-pixel compressively sensed architecture is exploited to simultaneously achieve a 10× reduction in acquired data compared with the Nyquist rate, while alleviating limitations faced by conventional widefield temporal focusing microscopes due to scattering of the fluorescence signal. Additionally, we demonstrate an adaptive sampling scheme that further improves the compression and speed of our approach.

We present a high-speed single pixel flow imager based on an all-optical Haar wavelet transform of moving objects. Spectrally-encoded wavelet measurement patterns are produced by chirp processing of broad-bandwidth mode-locked laser pulses. A complete wavelet pattern set serially illuminates the object via a spectral disperser. This high-rate structured illumination transforms the scene into a set of sparse coefficients. We show that complex scenes can be compressed to less than 30% of their Nyquist rate by thresholding and storing the most significant wavelet coefficients. Moreover by employing temporal multiplexing of the patterns we are able to achieve pixel rates in excess of 360 MPixels/s.