The CFD simulation accuracy mostly depends on the appropriate setting of boundary conditions and numerical simulation parameters. This study shows the influence of two types of boundary condition settings on the CFD simulation results of Double-Skin Façade (DSF) for a specific problem. These two boundary settings are the constant temperature on the DSF surfaces called Boundary A, and Boundary B is defined via solar radiation using the Discrete Ordinate radiation Model (DOM). The paper verified both the numerical simulations using the experimental data. Comparing the numerical results of two types of boundaries with experimental data shows that both cases underestimated the values lower than 5.2 K and 0.1 m/s for the temperature and velocity respectively at the regarded measured points. Boundary A gives more accurate temperature prediction results while Boundary B shows velocity magnitude closer to the measurements in the middle height of the cavity; the average temperature and velocity differences between the two boundary types are 0.6 K and, 0.003 m/s respectively which are negligible. Finally, the selection of boundary conditions depends on study purposes, however, when the DSF is equipped with blinds and if there is not enough data in hand but the exact value of solar irradiation, using the Boundary B approach is suggested; it can provide reasonable results associated with multi-type of thermal boundary conditions at the same time. Furthermore, if the goal is to investigate the flow pattern in the DSF, Boundary B is argued to perform better than the constant temperature boundary condition.

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Long non-coding RNAs (lncRNAs) are regulatory molecules that set many vital processes in the cell. These regulatory RNAs, as an important component of the regulatory networks of genes and the expression of key genes involved in setting development, play an important role in neurological diseases of the central nervous system (CNS). The purpose of this study was to evaluate the regulatory functions of lncRNAs in the evolution of the CNS and an overview of their roles in the biology of neuropsychiatric diseases. More than half of all lncRNAs expressed in CNS cells and their regulated expression in the evolution and function of the nervous system are important. lncRNAs are involved in the development of different parts of the brain, specificity and differentiation of oligodendrocytes category, and terminal myelination. In addition, they have a role in regulation of vital functions, such as maintaining neural stem cells, neurogenesis and glyogenesis, homeostasis, and synaptic connections. lncRNAs are associated with the biological processes in the brain, such as the development of the hippocampus and aging. Conclusion: This review has shown that how lncRNA regulate vital processes in neurons in order to have a better understanding on the mechanisms of neurological diseases by RNA interference. Understanding the role of the regulatory RNAs interference and its impact on the biology of CNS can helpful in the field of prognosis, prediction of response to treatment, and pathological staging. Furthermore, it can be inhibited or controlled as novel therapeutic targets.