Microwave (MWA) and radiofrequency ablation (RFA) are main ablative techniques for hepatocellular carcinoma (HCC) and colorectal liver metastasis (MT). This randomized phase 2 clinical trial compares the effectiveness of MWA and RFA as well as morphology of corresponding ablation zones. HCC and MT patients with 1.5–4 cm tumors, suitable for ablation, were randomized into MWA or RFA Groups. The primary endpoint was short-to-long diameter ratio of ablation zone (SLR). Primary technical success (TS) and a cumulative local tumor progression (LTP) after a median 2-year follow-up were compared. Between June 2015 and April 2020, 82 patients were randomly assigned (41 patients per group). For the per-protocol analysis, five patients were excluded. MWA created larger ablation zones than RFA (p = 0.036) although without differences in SLR (0.5 for both groups, p = 0.229). The TS was achieved in 98% (46/47) and 90% (45/50) (p = 0.108), and LTP was observed in 21% (10/47) vs. 12% (6/50) (OR 1.9 [95% CI 0.66–5.3], p = 0.238) of tumors in MWA vs. RFA Group, respectively. Major complications were found in 5 cases (11%) vs. 2 cases (4%), without statistical significance. MWA and RFA show similar SLR, effectiveness and safety in liver tumors between 1.5 and 4 cm.

Líneas de investigación recientes sobre el final de las uillae 2 y de los establecimientos rurales 3 del mundo romano permiten comprobar que los grandes complejos arquitectónicos rurales, uillae señoriales y aristocráticas tienen constatada una pervivencia mayor a aquella que tradicionalmente se había considerado siendo usados y reutilizados hasta momentos muy avanzados como son los siglos VI y VII. El estudio de estas transformaciones de las uillae en el Occidente romano en el periodo tardo-romano es una empresa imposible dentro de los límites de un trabajo como este. Aquí, por Transformación y final de las villae en occidente (siglos IV-VIII): problemas y perspectivas Gisela Ripoll * Javier Arce ** RESUMEN Análisis de las transformaciones que experimentan las uillae romanas en el occidente romano durante la antigüedad tardía comparando y contrastando la evidencia literaria y arqueológica y considerando las distintas interpretaciones dadas por historiadores y arqueólogos a este fenómeno.PALABRAS CLAVE: Transformaciones. Uillae. Occidente. Antigüedad tardía. ABSTRACTAnalysis of the transformations that Roman uillae underwent in the Roman West in the Late Roman period comparing and contrasting the literary and the archaeological evidence and thus considering the differing interpretations given by historians and archeologists to this phenomenon.

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