This study investigates the influence of feed solution pH and fouling on the rejection of ten selected pharmaceutically active compounds (PhACs) with different physicochemical characteristics (molecular weight, water solubility, log KOW, pKa, dipole moment…) by three multichannel ceramic ultrafiltration membranes, ranging from 1 to 8 kDa, in order to improve their removal from water. For this purpose, the comparison between filtration of PhACs in deionised water (Feed I) and in real wastewater effluent (Feed II) was performed, demonstrating that the variation of pH and the formation of a foulant layer altered the separation mechanism and hence the rejection values of each PhAC varied. Higher rejections of most of the PhACs were