Pure White Cell Aplasia (PWCA) is an extremely rare haematological entity. Various causes have been implicated in its pathogenesis. We are reporting here a case of a sixty seven years old female, referred to us with the concern of febrile neutropenia and extensive oral candidiasis. Workup for secondary causes of agranulocytosis was negative. Bone marrow findings were consistent with PWCA, and in the presence of convincing previous history of amodiaquine intake, she was diagnosed as drug (amodiaquine) induced PWCA.