Alveolar soft part sarcoma is a rare, aggressive malignancy of uncertain histologic origin and enigmatic clinical behaviour. It has a characteristic histopathological picture, with a propensity for vascular invasion and distant metastasis. We report a case of alveolar soft part sarcoma involving the tongue base in an adolescent female. She underwent laser assisted excision of the tongue base tumour followed by post-operative radiotherapy. The clinical presentation, histopathological picture, immunohistochemical & cytogenetic studies, radio-imaging, management protocols and prognosis of this tumor have been discussed.

Carcinomatous transformation of ectopic thyroid elements within the thyroglossal tract is a rare entity. We report a case of primary papillary carcinoma of thyroid presenting within the thyroglossal duct cyst in a 23 year old gentleman. The patient presented to us, as a case of suprahyoid thyroglossal cyst with sub-lingual involvement and he underwent surgical excision of the entire thyroglossal tract by Sistrunk's approach. The post-operative histopathological diagnosis was of a papillary carcinoma within the thyroglossal duct cyst. Hence, the patient was evaluated for a malignant focus in the thyroid which proved negative. He was counseled regarding the possibility of developing Carcinoma in the thyroid gland and offered two options of further management viz., total thyroidectomy followed by life long thyroid suppression or watchful observation and follow up. As the patient belonged to the low risk group, he opted for the second option. He is presently kept under meticulous follow up and remains asymptomatic till date. We present the pre-and post-operative imaging, intra-operative fi ndings, histo-pathological features and review the present world literature on this rare entity.

Introduction: Acid reflux disease of the larynx has been established as a separate clinical entity in the present day, requiring the nuances of a skilled laryngologist for its early diagnosis and appropriate management. Clinical presentations of laryngopharyngeal reflux disorder may vary from very subtle to mammoth proportions, ranging across a panorama of features like chronic laryngitis, indolent laryngeal ulcers or granulomas, onto life-threatening glottic/sub-glottic stenosis and laryngeal malignancies very rarely. With the advent of videostroboscopy, laryngologists have now acquired a 'cutting-edge' sensitive tool to look into the intricacies of the larynx and thereby study the pathological effects of laryngopharyngeal reflux in great detail.Objective: To assess the efficacy of videostroboscopy with voice analysis, as a diagnostic and prognostic tool in a cohort of patients with laryngopharyngeal reflux disorder.Study method: This prospective study was conducted over a two-year period, among 50 patients with hoarseness of voice and features of reflux laryngitis, who underwent videostroboscopy with voice analysis at initial diagnosis and at routine follow-up, to objectively study the response and outcome of anti-reflux therapy on the larynx.Observation and result: Videostroboscopy provided a vivid picture of the changes in larynx due to chronic acid reflux and proved efficacious in precisely judging the treatment responses. Conclusion:Our study reflects the recent concept highlighted in world literature that videostroboscopy is an ideal, sensitive tool for early diagnosis and in prognosis of acid induced laryngeal disorder.

Fungal infection of the larynx is a relatively uncommon condition. The lesions max be confined to the vocal folds or may involve various other sites in the larynx. There is, invariably, a risk factor that predisposes to fungal infection viz. immune deficiency, inhaled or systemic steroids, antibiotic usage, etc. These lesions may mimic malignancy or a premalignant condition. There have been very few cases of laryngeal thrush reported in the literature. Awareness of this entity is essential because the management depends on an accurate diagnosis. These lesions invariably respond to a course of oral antifungal therapy and correction of risk factors. We report 3 cases of laryngeal thrush.

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