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Multiprogrammable pacemakers have long been subject to inappropriate reprogramming and electromagnetic interference (EMI). A limited clinical experience with DDD pacing systems precludes the significance of such phenomena in these units. Since August 1981, in a series of 140 DDD systems, certain units demonstrated consistent and reproducible resetting to the back-up modes caused by electrocautery. One unit was permanently reset to the VOO mode. These observations suggest the need for renewed caution at the time of surgery; they also underscore the importance of a thorough understanding of any DDD system and careful follow-up so that such phenomena will not be misinterpreted as pacemaker failure, resulting in erroneous pacemaker removal.