In the last few years, molecular genetics analyses have permitted novel insights into psoriasis, a disease characterized by uncontrolled proliferation of keratinocytes and recruitment of T cells into the skin. The disease affects approximately 1-2% of the Caucasian population and can occur in association with other inflammatory diseases such as Crohn's disease and in association with human immunodeficiency virus (HIV) infection. Given that psoriasis has characteristics of an autoimmune disease, it is not surprising that HLA studies revealed an association with certain alleles, notably HLA-Cw6. Despite this HLA component, psoriasis in some families is inherited as an autosomal dominant trait with high penetrance. Loci at chromosome 17q25 and 4q have been identified following genome-wide linkage scans of large, multiply affected families. In the case of at least the susceptibility locus at 17q25, the development of psoriasis does not require the presence of HLA-Cw6. Sib-pair analyses have confirmed the association with HLA-Cw6, confirmed the existence of a locus at 17q25 and identified other possible susceptibility loci. Two independent groups have reported a third region on chromosome 20p. Despite these findings, the extent of genetic heterogeneity and the role of environmental triggers and modifier genes is still not clear. The precise role of HLA also still needs to be defined. The isolation of novel susceptibility genes will provide insights into the precise biochemical pathways that control this disease. Such pathways will also reveal additional candidate genes that can be tested for molecular alterations resulting in disease susceptibility.

G292.0+1.8 (G292) is a young (∼3000 yr), Galactic textbook-type core-collapse supernova remnant (CCSNR). It is characterized by X-ray, optical and infrared emission from ejecta and circumstellar medium (CSM) features, and contains a pulsar (PSR J1124-5916) and pulsar wind nebula that have been observed in X-rays and radio. Previous studies have revealed a complex, dynamically evolving, oxygen-rich remnant, a striking relic from the explosion of a massive star. Here, using our deep (530 ks) Chandra ACIS data, we present high spatial-resolution maps (based on a regional grid size of a few arcsec) of the shocked CSM and metal-rich ejecta in G292. We make the first Chandra-detection of Fe-rich ejecta in G292. We identify the X-ray counterpart of the northern equatorial belt, a component of a ring-like CSM structure identified earlier in the infrared band. We show the detailed spatial distributions of ejecta enriched in O, Ne, Mg, Si, S and Fe. We find that the bulk of the Si, S and Fe-rich X-ray-emitting ejecta are located in the northwestern hemisphere of the remnant, opposite to the pulsar's projected angular displacement to the southeast from the SNR's center. This suggests that the pulsar's kick may have originated from gravitational and hydrodynamic forces during an asymmetric explosion, rather than from anisotropic neutrino emission. Based on abundance ratios and our estimated CSM and ejecta masses, we constrain the progenitor mass to 13 M M 30 M

A novel 85-kDa protein secreted by the mouse stromal osteogenic cell line MN7 was identified using two-dimensional polyacrylamide gel electrophoresis (Mathieu, E., Meheus, L., Raymackers, J., and Merregaert, J. (1994) J. Bone Miner. Res. 9, 903-913). Degenerate primers were used to isolate the cDNA coding for this protein. The full-length cDNA clone is 1.9 kilobases (kb) and codes for a protein of 559 amino acid residues. The DNA and deduced amino acid sequences have no counterparts in public data bases, but a structural similarity involving typical cysteine doublets can be observed to serum albumin family proteins and to Endo16 (a calcium-binding protein of sea urchin). Northern blot analysis revealed the presence of a 1.9-kb transcript in various tissues, and a shorter transcript of 1.5 kb, derived by alternative splicing in tail, front paw and skin of embryonic mice. The gene for the p85 protein, termed Ecm1 (for extracellular matrix protein 1), is a single-copy gene, which was localized to the region on mouse chromosome 3 known to contain at least one locus associated with developmental disorders of the skin, soft coat (soc). Alternative splicing may serve as a mechanism for generating functional diversity in the Ecm1 gene.

We report on the results from the analysis of our 114 ks Chandra High Energy Transmision Grating Spectrometer observation of the Galactic core-collapse supernova remnant G292.0+1.8. To probe the three-dimensional structure of the clumpy X-ray emitting ejecta material in this remnant, we measured Doppler shifts in emission lines from metal-rich ejecta knots projected at different radial distances from the expansion center. We estimate radial velocities of ejecta knots in the range of −2300 v r 1400 km s −1 . The distribution of ejecta knots in velocity versus projected-radius space suggests an expanding ejecta shell with a projected angular thickness of ∼90 (corresponding to ∼3 pc at d = 6 kpc). Based on this geometrical distribution of the ejecta knots, we estimate the location of the reverse shock approximately at the distance of ∼4 pc from the center of the supernova remnant, putting it in close proximity to the outer boundary of the radio pulsar wind nebula. Based on our observed remnant dynamics and the standard explosion energy of 10 51 erg, we estimate the total ejecta mass to be 8 M , and we propose an upper limit of 35 M on the progenitor's mass.

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