Purpose Cardiovascular autonomic neuropathy (CAN) is one of the most common and serious complications associated with diabetes and is defined as the impairment of the autonomic control of the cardiovascular system, whose prevalence in Indian population has been reported to be > 50%. The risk factors associated with CAN include hyperglycemia, duration of diabetes, hypertension, dyslipidemia, and obesity. This study was conducted to examine the association of CAN with its determinants among diabetics. Methods Socio-demographic characteristics were noted alongwith performance of biochemical analyses of blood samples according to standard hospital pathology laboratory protocols. Clinical assessment of CAN comprised a of 5 indexes, including 3 heart rate variability parameters (resting tachycardia, Qtc interval > 440 msec, exercise intolerance) and 2 blood pressure parameters (orthostatic hypotension, abnormal hand gripping test).

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In this prospective study, two hundred and fifty four patients diagnosed to be having AVH were analyzed with reference to clinical profile & viral markers and statistical analysis was done. Isolated viral infection was documented in 102 (40.1%) patients where as more than one hepatotrophic viruses caused AVH in 27(10.6%) patients. Non A-E Virus was the major case of sporadic AVH (40.1%), HBV & HEV were the etiological agent in 23.6% & 25.1% respectively. HAV was detected in 16.5% of the patients and the HCV was incriminated rarely as cause of sporadic AVH. The demographic, clinical and biochemical profile amongst isolated & mixed viral infection were found to be similar. However, HBV-AVH had significant prolonged course (p<0.001) and HAV-AVH was found to have significantly higher number of patients pursing a course of relapsing hepatitis. However HAV infection amongst adults in the present study was not found to cause severe liver disease except in few cases.

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