The recent emergence of coronavirus disease 2019 (COVID-19) pandemic has reassessed the usefulness of historic convalescent plasma transfusion (CPT). This

AIMTo assess the correlation of HBA1C levels with left ventricular diastolic dysfunction in newly diagnosed Type 2 diabetic patient. This prospective study was done at Department of General Medicine, OPD, Medical Wards, Stanley Medical College and Hospital, Chennai. RESULTThe mean HBA1C levels were meaningfully more in Left Ventricular Diastolic Dysfunction (LVDD) positive group compared to the LVDD negative group by 1.33%. This significant difference of 15% increase in mean HBA1C levels in LVDD positive group compared to the LVDD negative group is true and has not occurred by chance. CONCLUSIONOne-fifth to one-third of diabetic patients will develop LVDD. Patients with HBA1C (8 to 10) have double the chances to develop LVDD than with HbA1c 6.5 to 8. Patients with HBA1C more than 10 have five times the chances to develop LVDD than with HbA1C 6.5 to 8. Patients with HBA1C more than 10 have three times the chances to develop LVDD than with HBA1C 8 to 10. One-fourth to one-half of diabetic patients will develop LVDD grade 1. Patients with HBA1C 8 to 10 have double the chances to develop LVDD grade 1 than with HBA1C 6.5 to 8. Patients with HBA1C more than 10 have four times the chances to develop LVDD grade 1 than with HBA1C 6.5 to 8. Patients with HBA1C more than 10 have two times the chances to develop LVDD than with HBA1C 8 to 10. KEYWORDSType 2 Diabetes, Left Ventricular Diastolic Dysfunction, HbA1C. HOW TO CITE THIS ARTICLE:Perumal V, Narayanan N, Rangarajan J, et al. A study to correlate HbA1C levels and left ventricular diastolic dysfunction in newly diagnosed type II diabetes mellitus.

Introduction: The Omicron variant rapidly outpaced Delta with documented community transmission in most countries and has led to an upsurge in cases in most regions. Since its initial detection from a specimen collected on November 8th 2021, Omicron amounted to 74.0% of the genome sequenced in South Africa and more than 99.0% in rest of the world. Objectives: 1. To describe the socio-demographic and clinical profile of Omicron cases treated at our tertiary care institution. 2. To assess the factors associated with the vaccination status of such Omicron cases. Methods: This observational study was conducted at a 500 bedded hospital in southern India from 15th of December 2021 to 5th of February 2022. Of the 333 COVID-19 patients who were registered with Reverse Transcription-Polymerase Chain Reaction (RT-PCR) positive result along with S Gene Target Failure (SGTF), 203 patients were included and were interviewed using a pre-designed semi-structured questionnaire. With prior approval from the Institutional Ethics Committee (IEC) data was collected and statistically analyzed with descriptive statistics and inferential statistics using SPSS software trial version 28.0 and OpenEpi software. At 95% confidence level, a P value of < 0.05 was considered as statistically significant. Results: Of the 203 cases studied, majority 149 (73.4%) were symptomatic, of which almost 114 (76.5%) had fever, 72 (48.3%) had cough and 29 (19.5%) had myalgia. 193 (95.1%) cases were categorized as mild, 8 (3.9%) as moderate and 2 (1.0%) as severe cases of COVID-19 with SGTF. Only 10 (4.9%) patients received supplementary oxygen support. Almost 158 patients (77.8%) were vaccinated against COVID-19 of which 106 (67%) were vaccinated with Covishield vaccine followed by 50 (31.7%) of them with Covaxin. 126 (79.7%) patients were completely vaccinated with two doses of any COVID-19 vaccine and 32 (20.3%) were partially vaccinated with a single dose of any COVID-19 vaccine. Among those who required supplemental oxygen (n = 10), the proportion of those vaccinated (40.0%) was lower com pared to those who were unvaccinated (60.0%). This association was statistically significant (P = 0.003, OR = 0.169, 95% CI of OR = 0.045, 0.628). Among the completely vaccinated subjects (n = 125), there was a statistically signifi-cant difference in mean (95% CI) interval between the last dose of vaccine taken and date of RT-PCR positivity with SGTF (P < 0.001). It was 186 (162, 210) days for Covaxin and was 131 (114, 148) days for Covishield vaccine. Conclusion: Omicron (SGTF) cases manifests mostly as mild cases with symptoms like fever, cough, myalgia and majority were independent of oxygen supplementation and had good prognosis. Omicron infection was delayed over six months among completely vaccinated subjects especially those who were vaccinated with Covaxin.

BACKGROUNDThis study was taken up to study the distribution of type of seizures and to evaluate the aetiological profile among patients presenting with seizures in a tertiary care centre