The in vitro activities of six commonly used antibiotics and six newer β-lactam agents were determined in 50 consecutive clinical isolates of β-lactamase-negative Neisseria gonorrhoeae . The gonococci isolated were notably resistant to penicillin, ampicillin, erythromycin, and tetracycline, whereas all of the strains were susceptible to the newer β-lactam agents cefoxitin and spectinomycin.

MICs of 20 2-acetylpyridine thiosemicarbazones and penicillin were determined for 25 clinical isolates of I8-lactamase-positive and P-lactamase-negative Neisseria gonorrhoeae strains. The compounds most active against the I8-lactamase-producing strains were the N4,N4-disubstituted derivatives and the thiosemicarbazone derivatives of the 2-acetylpyridines, followed by the other compounds related to the 2-acetylpyridine thiosemicarbazones.

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