Here we investigated consequences of interactions between long mGluR1a and short mGluR1b variants. Our results show, that mGluR1a interferes with mGluR1b trafficking to the cell surface in HEK293 transfected cells. Moreover, we show that swapping long mGluR1a and/or short mGluR1b C-termini with corresponding regions in chimerical GB1 and GB2 γ-amino butyric acid b (GABAb) receptor subunits does not exclude their heterodimerization.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.