Introduction: Gestational malaria is a major public health problem because it is a threat to pregnant women and their children. As Kisangani is a stable malaria transmission area and there is a paucity of data on the status of gestational malaria in our settings, we have found it appropriate to determine the prevalence of gestational malaria and its determinants in Kisangani City. Methods: We conducted a cross-sectional analytical study in Kisangani from January 1 to September 30, 2017. Our population study consisted of 1248 parturients recruited at delivery. We made the thick drop in peripheral blood from parturients at the admission and at the level of placental impressions after delivery. Results: The average age of the respondents was 25.3971 ± 6.2452 years; the overall prevalence of gestational malaria was 27.56% including 12.66% peripheral parasitaemia, 12.34% placental parasitaemia and 2.56% parasitaemia level and placental and peripheral blood impressions. Youngest age ≤ 18 years [OR (95% CI) = 2.44 (1.75-3.41), p < 0.001], primiparity [OR (95% CI) = 2.94 (2.00-4.32), p < 0.001] and positive HIV serology [OR (95% CI) = 3.01 (1.23-7.43), p = 0.008] increased the risk of gestational malaria; the use of mosquito net impregnated with insecticide [OR (95% CI) = 0.29 (0.14-0.61), p < 0.001] reduced this risk. Conclusion: The prevalence of gestational malaria is 27.56% in Kisangani. The youngest age ≤ 18 years, the primiparity and positive HIV serology of pregnant women were the most associated risk factors.

Introduction: Hysterosalpingography is an important tool in the investigation of the causes of female infertility. In developing countries such as the Democratic Republic of Congo, the HSG is the basic tool for performing first-line anatomical (pelvic) assessment. The aim of this study is to determine the prevalence of the different lesions observed in hysterosalpingography carried out during the assessment of infertile women monitored in Kisangani. The study set also out to look for differences in these lesions according to the type of infertility. Methods: This cross-sectional study was conducted in Kisangani from June 2016 to December 2018. The 130 cases of hysterosalpingography performed for female infertility assessment during the study period were included, of which 33.07% for primary infertility and 66.93% for secondary infertility. Results: The mean age of the patients was 33.52 ± 6.01 years; the history of pelvic inflammatory disease was noted with a predominance for secondary infertility (11% vs. 4.65%). Using hysterosalpingography, 7 (5.38%) patients had a normal result; 94 (72.31%) had tubal obstruction; 25 (19.23%) had hydrosalpinx; 11 (8.46%) had uterine fibroids; pelvic adhesions were suspected in 12.64% of cases. There was no obvious association between all these lesions and the type of infertility. Conclusion: We found that tubal obstructions were the most prevalent lesions in this study, regardless of the type of infertility. These lesions would reflect the high prevalence of septic abortions and sexually transmitted infections in developing countries such as the Democratic Republic of the Congo.

Background In sub-Saharan Africa, tubal factors are described as the main etiological factor of infertility. Under these conditions, medically assisted procreation is particularly indicated. However, ART centers are less available. Thus, infertile couples are quickly oriented towards available conventional alternative treatment. The present study aimed to determine the etiological factors of infertility, the outcomes of the therapeutic options offered, and the factors associated with the success of conventional treatment in infertile couples seeking tertiary care in Kisangani.Methods a cross-sectional study was conducted in two tertiary-level health facilities in Kisangani. Consented infertile couples underwent specific examinations necessary for the exploration of infertility and were treated and followed for a minimum of 6 months. The therapeutic option to be offered could relate to the expectant attitude, medical treatment, surgical treatment or transfer to an in vitro fertilization unit. The pregnancy diagnosis was done by ultrasound.Results A total of 272 infertile couples underwent specific examinations, then were treated and followed for a minimum of 6 months. Many determinant causes are mostly linked to wives than husbands. Overall, only 34 women among 211 treated got pregnant during the follow-up period; 61 couples were advised to resort to IVF or adoption, but the couples for whom the expectant attitude was indicated, had immediately rejected it. The patients who therapeutically succeeded at the end of the treatment were those whose age was less than 35 years (OR = 2.27; 95% CI = 1.06–4.87; P = 0.017), the duration of infertility was less than five years (OR = 6.08; 95% CI = 1.79–20.69; P = 0.001) and those with secondary infertility (OR = 6.08; 95% CI = 1.79–20.69; P = 0.001).Conclusion The etiological particularities, with the predominance of tubal factors, do not allow extend effective treatment without ART techniques. This study constitutes a genuine plea to stimulate national policies to take an interest in infertility questions.

Kisangani is an area with intense malaria transmission and sulfadoxinepyrimethamine resistance. Alternative antimalaria prophylaxis medication and protocols are needed, particularly with pregnant individuals. In this study, we compare the tolerance and effectiveness of mefloquine regimen as a split dose with a meal vs.sulfadoxine-pyrimethamine for the intermittent preventive treatment in pregnant individuals in Kisangani.Methods: This study was conducted from 15 May to 30 November 2019 as a singleblind, randomized clinical trial comparing 2 regimens of intermittent preventive treatment during pregnancy. The first regimen consisted of 4 doses of sulfadoxinepyrimethamine, and the second of 2 doses of mefloquine taken as a split dose with meal.

Background In sub-Saharan Africa, tubal factors are described as the main aetiological factors of infertility. Under these conditions, medically assisted procreation is particularly indicated. However, Assisted Reproductive Technology centres are less available. Thus, infertile couples are quickly oriented towards available alternative conventional treatments. The present study aimed to determine the aetiological factors of infertility, the outcomes of the therapeutic options offered, and the factors associated with the success of conventional treatment among infertile couples seeking tertiary care in Kisangani. Methods A cross-sectional study was conducted at two tertiary health facilities in Kisangani. Infertile couples who provided consent underwent specific examinations necessary for the exploration of infertility and were treated and followed up for a minimum of 6 months. The therapeutic options that were offered were expectant attitude, medical treatment, surgical treatment or transfer to an in vitro fertilization unit. The pregnancy diagnosis was performed by ultrasound. Results A total of 272 infertile couples underwent specific examinations, were treated and were followed up for a minimum of 6 months. Many determinant causes were mostly linked to wives rather than husbands. Overall, only 34 women among 211 who were treated became pregnant during the follow-up period; 61 couples were advised to resort to IVF or adoption, but the couples for whom expectant the attitude was indicated immediately rejected it. The patients who therapeutically succeeded at the end of the treatment were those who were younger than 35 years (OR = 2.27; 95% CI = 1.06–4.87; P = 0.017), had a duration of infertility of less than five years (OR = 6.08; 95% CI = 1.79–20.69; P = 0.001) and had secondary infertility (OR = 6.08; 95% CI = 1.79–20.69; P = 0.001). Conclusion Kisangani faces a major issue in the treatment of infertility. Treatment of patients using conventional methods is limited by the predominance of tubal factors as aetiological determinants of infertility. The low pregnancy rate found in this study provided additional evidence of this. This paper represents a serious plea to national policy-makers to encourage them to pay attention to issues surrounding infertility.