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Aims Determine efficacy of “KARER” educational intervention on caring ability and burden of caregiving relatives of disabled patients with stroke and cardiovascular diseases. Design Clinical, randomized, controlled and double blinded trial with a mixed approach. Methods Study population will be made up of 96 caregiving relatives of patients of home‐hospitalized care programs in the cities of Bogotá and Bucaramanga, (Colombia), between March 2021 and March 2022. Participants will be randomly assigned into two groups, either intervention ( n = 48) or control ( n = 48). The intervention is interdisciplinary and multi‐component: B‐Learning modality and clinical simulation. Follow‐up of participants will last 8 weeks from intervention period start‐out, and measurements will be taken and analysed in masked form. The main results will be the mean score changes of care ability and caregiver burden. Discussion Caregiving relatives will show better adaptation to their role through effective use of caring abilities as they look after disabled persons with chronic diseases.