Objective:To determine the effect of fenoldopam infusion on urine output, sodium excretion, creatinine clearance, and indirect blood pressure in healthy cats. Design: Prospective study. Setting: Veterinary medical teaching hospital. Animals: Eight purpose-bred cats, 2-4 years old. Interventions: None. Measurements: Urine output was measured hourly for 12 hours before and after fenoldopam administration. Sodium excretion, modified creatinine clearance, and fractional sodium excretion were measured before and following fenoldopam administration. Urine specific gravity, central venous pressure, and systolic blood pressure were measured every 4 hours during the experiment.Main results: Compared with pre-infusion values, urine output, sodium excretion, and fractional excretion of sodium increased significantly 6 hours after initiation of fenoldopam infusion. This increase was sustained throughout the observation period. The modified creatinine clearance decreased significantly following 2 hours of fenoldopam infusion, but increased significantly by 6 hours after infusion, the time of peak urine output. Changes in urine specific gravity mirrored changes in fractional sodium excretion, whereas the central venous pressure mirrored changes in modified creatinine clearance. The diuretic effect in cats was prevented when a dopamine receptor blocking agent was administered before fenoldopam infusion. Conclusion: Fenoldopam at a dose of 0.5 mg/kg/min induces diuresis in cats in a delayed manner. This increase appears to be due, in part, to dopamine receptor-induced natriuresis. Changes in glomerular filtration rate may also occur. (J Vet Emerg Crit Care 2006; 16(2): 96-103)

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Magnetic resonance imaging (MRI) findings of two cases with intracranial disease and pigmented intraorbital prosthetics are presented. A brown prosthetic (Case 1) caused a significant magnetic susceptibility artifact, which necessitated removal to properly image the brain. The artifact observed on MRI images is likely due to ferromagnetic pigments used for coloring. A black prosthetic (Case 2) caused no imaging artifact. The carbon-based pigments used to color the black prosthetic implant do not appear to cause imaging artifact. The pigments currently used to color the brown pigmented orbital prostheses cause significant magnetic susceptibility artifact and may require removal to evaluate the brain and surrounding structures completely.

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2016-12-24T18:10:15