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Deep Learning has established itself to be a common occurrence in the business lexicon. The unprecedented success of deep learning in recent years can be attributed to: an abundance of data, availability of gargantuan compute capabilities offered by GPUs, and adoption of open-source philosophy by the researchers and industry. Deep neural networks can be decomposed into a series of different operators. MIOpen, AMD's open-source deep learning primitives library for GPUs, provides highly optimized implementations of such operators, shielding researchers from internal implementation details and hence, accelerating the time to discovery. This paper introduces MIOpen and provides details about the internal workings of the library and supported features. MIOpen innovates on several fronts, such as implementing fusion to optimize for memory bandwidth and GPU launch overheads, providing an auto-tuning infrastructure to overcome the large design space of problem configurations, and implementing different algorithms to optimize convolutions for different filter and input sizes. MIOpen is one of the first libraries to publicly support the bfloat16 data-type for convolutions, allowing efficient training at lower precision without the loss of accuracy.

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It is widely accepted that cellular requirements and environmental conditions dictate the architecture of genetic regulatory networks. Nonetheless, the status quo in regulatory network modeling and analysis assumes an invariant network topology over time. In this paper, we refocus on a dynamic perspective of genetic networks, one that can uncover substantial topological changes in network structure during biological processes such as developmental growth. We propose a novel outlook on the inference of time-varying genetic networks, from a limited number of noisy observations, by formulating the network estimation as a target tracking problem. We overcome the limited number of observations (small n large p problem) by performing tracking in a compressed domain. Assuming linear dynamics, we derive the LASSO-Kalman smoother, which recursively computes the minimum mean-square sparse estimate of the network connectivity at each time point. The LASSO operator, motivated by the sparsity of the genetic regulatory networks, allows simultaneous signal recovery and compression, thereby reducing the amount of required observations. The smoothing improves the estimation by incorporating all observations. We track the time-varying networks during the life cycle of the Drosophila melanogaster. The recovered networks show that few genes are permanent, whereas most are transient, acting only during specific developmental phases of the organism.

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