Objective:to estimate the prevalence of TaqIA, -141C and rs6280 polymorphisms of the ANKK1, DRD2 and DRD3 genes and evaluate their association with the occurrence of metabolic syndrome in patients with refractory schizophrenia. Method:cross-sectional study conducted in the Extended Western Region of Minas Gerais, with refractory schizophrenic patients using the antipsychotic clozapine. Sociodemographic, clinical, anthropometric, biochemical and genetic data were collected. Univariate analysis of the data was performed. Results:seventy-two patients participated in the study and the occurrence of Metabolic Syndrome was observed in 47.2% of them. There was no association between Metabolic Syndrome and the studied polymorphisms. There was a statistically significant difference in the low HDL parameter with homozygous genotype for the C allele of the -141C polymorphism of the DRD2 gene. Conclusion:a high prevalence of MS was evidenced. The -141C polymorphism was associated with low HDL. Genetic analysis and identification of metabolic alterations in this group of patients can guide drug treatment and provide a better quality of life.

Objective: To analyze the quality of life of people with refractory schizophrenia using clozapine, and its associated factors. Methods: A cross-sectional study, conducted in the extended western region of Minas Gerais, which included patients with refractory schizophrenia using the antipsychotic, clozapine. For the measurement of quality of life, the Quality of Life Scale was used, specific for patients with schizophrenia. Univariate and multivariate analyses were performed. Results: A total of 72 patients with a mean age of 42.9 years was part of the study. The overall score of the Quality of Life Scale indicated compromised quality of life, with a greater impairment in the social network domain (median = 2.36). The logistic regression analysis showed factors associated with a better quality of life. Conclusion: Low quality of life in patients with refractory schizophrenia was found. Physical activity, family income over three times the minimum wage, and having children were associated with a better quality of life. ResumoObjetivo: Analisar a qualidade de vida de pessoas com esquizofrenia refratária em uso de clozapina e seus fatores associados. Métodos: Estudo de delineamento transversal, realizado na Região Ampliada Oeste de Minas Gerais, que incluiu pacientes com esquizofrenia refratária em uso do antipsicótico clozapina. Para a mensuração da qualidade de vida, foi utilizada a escala Quality of Life Scale, específica para pacientes com esquizofrenia. Foram realizadas análise univariada e multivariada. Resultados: Participaram 72 pacientes, com média de idade de 42,9 anos. O escore global da Quality of Life Scale indicou qualidade de vida comprometida, com maior prejuízo no domínio rede social (mediana = 2,36). A análise de regressão logística apontou fatores associados a uma melhor qualidade de vida. Conclusão: Evidenciou-se uma baixa qualidade de vida dos pacientes com esquizofrenia refratária. Praticar atividade física, renda familiar acima de três salários mínimos e possuir filhos foram associados à melhor qualidade de vida.

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RESUMOObjetivo: traçar o perfil sociodemográfico e clínico dos pacientes com esquizofrenia refratária que fazem uso do antipsicótico clozapina de acordo com a presença de síndrome metabólica. Método: Trata-se de um estudo epidemiológico de delineamento descritivo e transversal. A amostra final foi composta por 72 participantes que atenderam aos critérios de inclusão. Foram coletados dados sociodemográficos, clínicos, antropométricos e bioquímicos. Realizou-se análise descritiva dos dados. Resultados: Observou-se que a presença de síndrome metabólica em mulheres (58,8%) foi superior aos homens (41,2%). Os pacientes apresentaram percentuais mais elevados de alterações nos componentes da síndrome, principalmente glicemia e triglicérides. 65% dos pacientes fazem uso de quatro ou mais medicamentos e 47,1% dos indivíduos apresentaram sobrepeso e 38,2% obesidade. Conclusão: Sugere-se a construção de estratégias de prevenção primária das alterações metabólicas, bem como a monitoração continuada de suas questões clínicas, principalmente em relação aos componentes da síndrome. Descritores: Perfil de saúde; Características da população; Esquizofrenia; Clozapina; Síndrome x metabólica.ABSTRACT Objective: to trace the sociodemographic and clinical profile of patients with refractory schizophrenia that make use of antipsychotic clozapine according to the presence of metabolic syndrome. Method: This is an epidemiological study of descriptive and cross-sectional design. The sample consisted of 72 patients who met the inclusion criteria. Sociodemographic, clinical, anthropometric and biochemical data were collected. It was realized descriptive analysis of data. Results: It was observed that the presence of metabolic syndrome it was higher in women (58.8%) of than men (41.2%). Patients had higher percentages of changes in the components of the syndrome, especially glucose and triglycerides. 65% of patients make use of four or more drugs and 47.1% of subjects were overweight and 38.2% obese. Conclusion: it is suggested that the construction of primary prevention strategies of metabolic changes as well as continued monitoring of clinical issues, especially regarding the components of the syndrome. Descriptors: Health profile; Population characteristics; Schizophrenia; Clozapine; Metabolic syndrome x. RESUMEN Objetivo: trazar el perfil sociodemográfico y clínico de los pacientes con esquizofrenia refractaria que hacen uso de la clozapina antipsicótica de acuerdo con la presencia de síndrome metabólico. Método: Se trata de un estudio transversal epidemiológico. La muestra consistió en 72 pacientes que cumplían los criterios de inclusión. Se recogieron datos sociodemográficos, clínicos, antropométricos y bioquímicos. Un análisis descriptivo de los datos. Resultados: se observó que la presencia de síndrome metabólico en las mujeres (58,8%) fue mayor que en los hombres (41,2%). Los pacientes tenían mayores porcentajes de cambios en los componentes del síndrome, sobre todo glucosa y triglicéridos. 65% de los pacientes hacen uso de cuatro...

This research aimed to evaluate the reproductive, gynecological, sexual and clinical aspects of women with mental disorders. This is an exploratory research with quantitative approach performed in a Psychosocial Care Center, Type III, in Divinópolis, Minas Gerais, Brazil, with 39 women with mental disorders. Data collection took place from October to December 2012, through used semi-structured interviews and checked blood pressure, blood glucose, weight and height. The results revealed normal levels of blood pressure and postprandial blood glucose, change in body mass index, presence of menstrual flow, nulliparity, first sexual intercourse in adolescence, early menarche, and lack of climacteric symptoms and history of abortion. Comprehensive health care for women involves more than the demands and needs of the mental health field.