Highly soluble, non-aggregated colloidal wurtzite InN nanocrystals were obtained through an ambient pressure, low-temperature method followed by post-synthesis treatment with nitric acid.
Prevention of pulmonary Pseudomonas aeruginosa infections represents a critical unmet medical need for cystic fibrosis (CF) patients. We have examined the tenet that a mucosal immunization approach can reduce interactions of a piliated form of this opportunistic pathogen with respiratory epithelial cells. Vaccinations were performed using ntPEpilinPAK, a protein chimera composed of a nontoxic form of P. aeruginosa exotoxin A (ntPE), where the C-terminal loop amino acid sequence of the PAK strain pilin protein was inserted in place of the ntPE Ib domain. Intranasal (i.n.) immunization of BALB/c mice with ntPEpilinPAK generated both serum and saliva immune responses. A series of in vitro studies showed that diluted samples of saliva obtained from immunized mice reduced pilin-dependent P. aeruginosa binding to polarized human tracheal epithelial cells, protected human pulmonary epithelial cells from cytotoxic actions associated with bacterial challenge, and reduced exotoxin A toxicity. Overall, i.n. administration of ntPEpilinPAK induced mucosal and systemic immune responses that may be beneficial for blocking early stage adhesion and/or infection events of epithelial cell-P. aeruginosa interactions at oropharyngeal surfaces.
During Taiwan's transition from authoritarian rule to liberal governance in the 1970s–80s, the government introduced a noise‐control system that uses technological instruments to manage citizens’ everyday noise problems. Rather than reducing noise problems, however, the system has amplified the disparity between a sound that is heard and one that is measured, calling into question the efficacy of noise control to attend to citizens’ needs. For residents and state actors in Taipei, the contradiction underlying noise control forms a lived condition of urban life, one that has initiated sono‐sociality, or social relations that emerge through efforts to communicate and interact with sound. [sound, noise, acoustemology, environment, governance, urban, Taipei, Taiwan]
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