This paper discusses the constitution relation within the framework of the mechanistic approach to neurobiological explanation. It develops a regularity theory of constitution as an alternative to the manipulationist theory of constitution advocated by some of the proponents of the mechanistic approach. After the main problems of the manipulationist account of constitution have been reviewed, the regularity account is developed based on the notion of a minimal type relevance theory. A minimal type relevance theory expresses a minimally necessary condition of a given type that consists of a disjunction of minimally sufficient conditions of that type. Afterwards, the attained definition is successfully applied in an analysis of the logical structure of the explanation of spatial learning and memory in rats as a paradigm neurobiological explanation. The overall result is a more robust and more precise version of the mechanistic approach to neurobiological explanations.

This paper discusses the relevance of models for cognitive science that integrate mechanistic and computational aspects. Its main hypothesis is that a model of a cognitive system is satisfactory and explanatory to the extent that it bridges phenomena at multiple mechanistic levels, such that at least several of these mechanistic levels are shown to implement computational processes. The relevant parts of the computation must be mapped onto distinguishable entities and activities of the mechanism. The ideal is contrasted with two other accounts of modeling in cognitive science. The first has been presented by David Marr in combination with a distinction of “levels of computation”. The second builds on a hierarchy of “mechanistic levels” in the sense of Carl Craver. It is argued that neither of the two accounts secures satisfactory explanations of cognitive systems. The mechanistic-computational ideal can be thought of as resulting from a fusion of Marr’s and Craver’s ideals. It is defended as adequate and plausible in light of scientific practice, and certain metaphysical background assumptions are discussed.

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Mental and neural states are related to one another by vertical (synchronic) interlevel relations and by horizontal (diachronic) intralevel relations. For particular choices of such relations, problems arise if causal efficacy is ascribed to mental states. In a series of influential papers and books, Kim has presented his much discussed "supervenience argument", which ultimately amounts to the dilemma that mental states either are causally inefficacious or they hold the threat of overdetermining neural states. Forced by this disjunction, Kim votes in favor of overdetermination and, ultimately, reduction. We propose a perspective on mental causation that dissolves the assumption of a tension between horizontal and vertical determination. For mental states to be causally efficacious, they must be dynamically stable. This important requirement can be implemented by combining a key idea of supervenience, multiple realization, with the recently introduced vertical interlevel relation of contextual emergence. Both together deflate Kim's dilemma and reflate the causal efficacy of mental states.