Purpose: The purpose of this study was to evaluate the effectiveness of foot reflexology on fatigue, sleep and pain. Methods: A systematic review and meta-analysis were conducted. Electronic database and manual searches were conducted on all published studies reporting the effects of foot reflexology on fatigue, sleep, and pain. Forty four studies were eligible including 15 studies associated with fatigue, 18 with sleep, and 11 with pain. The effects of foot reflexology were analyzed using Comprehensive Meta-Analysis Version 2.0. The homogeneity and the fail-safe N were calculated. Moreover, a funnel plot was used to assess publication bias. Results: The effects on fatigue, sleep, and pain were not homogeneous and ranged from 0.63 to 5.29, 0.01 to 3.22, and 0.43 to 2.67, respectively. The weighted averages for fatigue, sleep, and pain were 1.43, 1.19, and 1.35, respectively. No publication bias was detected as evaluated by fail-safe N. Foot reflexology had a larger effect on fatigue and sleep and a smaller effect on pain. Conclusion: This meta-analysis indicates that foot reflexology is a useful nursing intervention to relieve fatigue and to promote sleep. Further studies are needed to evaluate the effects of foot reflexology on outcome variables other than fatigue, sleep and pain.

CCQM-K120.a comparison involves preparing standards of carbon dioxide in air which are fit for purpose for the atmospheric monitoring community, with stringent requirements on matrix composition and measurement uncertainty of the CO2 mole fraction. This represents an analytical challenge and is therefore considered as a Track C comparison. The comparison will underpin CMC claims for CO2 in air for standards and calibrations services for the atmospheric monitoring community, matrix matched to real air, over the mole fraction range of 250 μmol/mol to 520 μmol/mol. CCQM-K120.b comparison tests core skills and competencies required in gravimetric preparation, analytical certification and purity analysis. It is considered as a Track A comparison. It will underpin CO2 in air and nitrogen claims in a mole fraction range starting at the smallest participant's reported expanded uncertainty and ending at 500 mmol/mol. Participants successful in this comparison may use their result in the flexible scheme and underpin claims for all core mixtures This study has involved a comparison at the BIPM of a suite of 44 gas standards prepared by each of the participating laboratories. Fourteen laboratories took part in both comparisons (CCQM-K120.a, CCQM-K120.b) and just one solely in the CCQM-K120.b comparison. The standards were sent to the BIPM where the comparison measurements were performed. Two measurement methods were used to compare the standards, to ensure no measurement method dependant bias: GC-FID and FTIR spectroscopic analysis corrected for isotopic variation in the CO2 gases, measured at the BIPM using absorption laser spectroscopy. Following the advice of the CCQM Gas Analysis Working Group, results from the FTIR method were used to calculate the key comparison reference values. KEY WORDS FOR SEARCH FTIR, CO2, GC-FID, Carbon dioxide at background level, Carbon dioxide at urban level, Delta Ray, CO2 gas standards Main text To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/. The final report has been peer-reviewed and approved for publication by the CCQM, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).

To understand the carbon cycle at policy-relevant spatial scales, a high density of high-quality CO 2 measurement sites is needed. In 2012, the Korea Meteorological Administration (KMA) installed CO 2 monitoring systems at Anmyeondo (AMY) in the west, Jejudo Gosan Suwolbong (JGS) in the southwest, and Ulleungdo (ULD) in the east of South Korea. Three stations were instrumented with identical greenhouse gas measurement systems based on cavity ring-down spectroscopy (CRDS) and a new drying system developed by KMA and the Korea Research Institute of Standards and Science (KRISS). This drying system is suitable in humid areas; water vapor measured using CRDS in ambient air was 0.001 % to 0.004 % across the stations. Measurement uncertainties expressed by the quadrature sum of the uncertainties from the drying system, scale propagations, repeatability, and reproducibility were ∼ 0.11 ppm from all KMA stations in the 68 % confidence interval. Average monthly CO 2 enhancements above the local background at each station were 4.3 ± 3.3 ppm at AMY, 1.7 ± 1.3 ppm at JGS, and 1 ± 1.9 ppm (1σ ) at ULD, respectively, during 2012 to 2016. At AMY station, located between China and South Korea, CO 2 annual means and seasonal variations are also greater than the other KMA stations, indicating that it is affected not only by local vegetation, but also added anthropogenic sources. Selected baseline CO 2 at AMY and at JGS in the west of South Korea is more sensitive to East Asia (e.g., China) according to wind direction and speed. Through the comparison of long-term trends and growth rates at AMY with other East Asian stations over 15 years, it was suggested that they could be affected not only by local vegetation but also by measurement quality.Published by Copernicus Publications on behalf of the European Geosciences Union.

Porphyromonas gingivalis (P.g.), which is a potential pathogen for periodontal diseases, contains lipopolysaccharide (LPS), and this endotoxin stimulates a variety of cellular responses. At present, P.g.-derived LPS-induced cellular responses in human periodontal ligament fibroblasts (PDLFs) are not well characterized. Here, we demonstrate that P.g-derived LPS regulates inflammatory responses, apoptosis and differentiation in PDLFs. Interleukin-6 (IL-6) and -8 (IL-8) were effectively upregulated by treatment of P.g.-derived LPS, and we confirmed apoptosis markers including elevated cytochrome c levels, active caspase-3 and morphological change in the presence of P.g.-derived LPS. Moreover, when PDLFs were cultured with differentiation media, P.g.-derived LPS reduced the expression of differentiation marker genes, as well as reducing alkaline phosphatase (ALP) activity and mineralization. P.g.-derived LPS-mediated these cellular responses were effectively abolished by treatment of mitogen-activated protein kinase (MAPK) inhibitors. Taken together, our results suggest that P.g.-derived LPS regulates several cellular responses via activation of MAPK signaling pathways in PDLFs.

In this study, standard gas mixtures of SF in synthetic air were gravimetrically developed as a suite consisting of 6 mixtures with mole fractions of SF ranging from 5 to 15 pmol/mol. For precision in weighing the gas fills, an automatic weighing system coupled with a high sensitivity mass balance was used and a gravimetry precision of 3 mg (2σ) was achieved. Impurity profiles of the raw gases were determined by various analyzers. In particular, sub pmol/mol levels of SF in the matrix components (N, O, and Ar) were carefully measured, since the mole fraction of SF in the final step can be significantly biased by this trace amount of SF in the raw gases of the matrix components. Gravimetric dilution of SF by purity-assessed N was performed in 6 steps to achieve a mole fraction of 440 pmol/mol. In the final step, O and Ar were added to mimic the atmospheric composition. Gravimetric fractions of SF and the associated standard uncertainty in each step were computed according to the ISO 6142 and JCGM 100:2008, respectively, and validated experimentally. Eventually, the SF fraction uncertainty of the standard gas mixtures combined by uncertainties of gravimetric preparation and verification measurements were found to be nominally 0.08% at a 95% confidence interval. A comparison with independent calibration standards from NOAA shows agreement within 0.49%, satisfying the extended WMO compatibility goal, 0.05 ppt.