It is known that emotions are part of the human being, directly influencing the immune system and in today's society stress is considered as one of the biggest problems in people's lives. Communication of the brain-intestine-microbiota axis may have altered functions for several reasons, including a change in the intestinal microbiota. This article aims to discuss the relationship between the digestive system and emotions. This is an integrative review of the literature. Stress induces changes in the microbiota, such as the predominance of a bacterium over other phylum's, which may affect the behavior of the brain, inducing the release of inflammatory cytokines that damage the brain neurochemical, leaving the individual more susceptible to anxiety and depression, which may clarify the association between inflammatory bowel disease and mental disorders. It is evident that there is a relationship between the digestive system and emotions, as well as with the normal microbiota and the immune system, through the gut-brain-microbiota axis.