Video delivery is exploiting 5G networks to enable higher server consolidation and deployment flexibility. Performance optimization is also a key target in such network systems. We present a multi-objective optimization framework for service function chain deployment in the particular context of Live-Streaming in virtualized content delivery networks using deep reinforcement learning. We use an Enhanced Exploration, Dense-reward mechanism over a Dueling Double Deep Q Network (E2-D4QN). Our model assumes to use network function virtualization at the container level. We carefully model processing times as a function of current resource utilization in data ingestion and streaming processes. We assess the performance of our algorithm under bounded network resource conditions to build a safe exploration strategy that enables the market entry of new bounded-budget vCDN players. Trace-driven simulations with real-world data reveal that our approach is the only one to adapt to the complexity of the particular context of Live-Video delivery concerning the state-of-art algorithms designed for general-case service function chain deployment. In particular, our simulation test revealed a substantial QoS/QoE performance improvement in terms of session acceptance ratio against the compared algorithms while keeping operational costs within proper bounds.

No abstract

This work presents DeepReGraph, a novel method for co-clustering genes and cis-regulatory elements (CREs) into candidate regulatory networks. Gene expression data, as well as data from three CRE activity markers from a publicly available dataset of mouse fetal heart tissue, were used for DeepReGraph concept proofing. In this study we used open chromatin accessibility from ATAC-seq experiments, as well as H3K27ac and H3K27me3 histone marks as CREs activity markers. However, this method can be executed with other sets of markers. We modelled all data sources as a heterogeneous graph and adapted a state-of-the-art representation learning algorithm to produce a low-dimensional and easy-to-cluster embedding of genes and CREs. Deep graph auto-encoders and an adaptive-sparsity generative model are the algorithmic core of DeepReGraph. The main contribution of our work is the design of proper combination rules for the heterogeneous gene expression and CRE activity data and the computational encoding of well-known gene expression regulatory mechanisms into a suitable objective function for graph embedding. We showed that the co-clusters of genes and CREs in the final embedding shed light on developmental regulatory mechanisms in mouse fetal-heart tissue. Such clustering could not be achieved by using only gene expression data. Function enrichment analysis proves that the genes in the co-clusters are involved in distinct biological processes. The enriched transcription factor binding sites in CREs prioritize the candidate transcript factors which drive the temporal changes in gene expression. Consequently, we conclude that DeepReGraph could foster hypothesis-driven tissue development research from high-throughput expression and epigenomic data. Full source code and data are available on the DeepReGraph GitHub project.

No abstract