Benign prostatic hyperplasia (BPH) is a condition intimately related to ageing. Currently available treatment options for the management of BPH have various limitations and associated adverse effects. A polyherbal formulation is claimed to be beneficial in patients with benign prostatic hyperplasia. This single blind, placebo-controlled study evaluated the clinical efficacy and safety of polyherbal formulation in BPH. Material and Methods: A total of 60 patients who were diagnosed as BPH and who were willing to give informed consent were included in the study. At the randomization visit, a detailed medical history was obtained and the patients underwent a thorough systemic examination and digital rectal examination. Routine blood analysis, urinalysis and serum levels of prostate specific antigen were carried out. Abdominal pelvic ultrasonography was done at entry and after completing the study. The severity of the urinary parameters was evaluated using American Urological Association symptom score. All the patients were randomized using random table into either polyherbal group (n = 30) or placebo (n = 30). Each patient received either polyherbal formulation or placebo in a dose of 2 capsules twice a day with meals for two months. All adverse events reported by the patients or observed by investigators were recorded. Statistical analysis was done according to the intention-to-treat principles. Analysis was performed between the groups using Fisher's exact test or unpaired "t" test (Independent t-test). Results: Fifty-six patients completed the study. There was a significant improvement in the mean AUA symptom score, PVR urine volume urinary hesitancy, intermittent flow, straining during urination, sense of incomplete micturition and frequency of night-time urination, in the polyherbal formulation group. Four patients from the placebo group withdrew from the study due to lack of benefit to the treatment. Conclusion: The beneficial clinical efficacy of polyherbal formulation observed in this study in the management of BPH could be due to the synergistic actions of its potent herbs. This polyherbal formulation was well tolerated and safe.

The results of this study indicated that bipolar resection of bladder tumours have lower incidence of complications especially bleeding, TUR syndrome, obturator jerks and bladder perforation. Bipolar TURBT is safe and efficacious in managing bladder tumours.

Objective The primary aim of the study was to study the histological changes (Thermal artefacts) noted in the resected specimens between the Monopolar and Bipolar Trans-Urethral Resection of Bladder Tumours (TURBT). Patients and Methods The study was done between March 2012 and Feb 2013. This was a comparative study between Monopolar and Bipolar resection specimens studied for histological changes (Thermal artefacts). Institutional Ethics Committee approval was obtained. Informed consent was taken from all patients. Patients were randomized into two groups, Monopolar Group or Bipolar Group of 50 each to undergo TURBT. Patients either underwent Monopolar or Bipolar TURBT in Glycine and Saline respectively. Results Thermal artefacts were graded according to WHO (World Health Organization) grading system. There was no difficulty noticed during histo-pathological examination of resected specimens. In Monopolar group, there were 27 (54%) grade 2 thermal damage, 17 (34%) grade 1 thermal damage and no grade-3 thermal damage in examined specimen. In Bipolar group, there were 07 (14%) grade 2 thermal damage, 12 (24%) grade 1 thermal damage and no grade 3 thermal damage in examined specimen. Conclusion The degree of thermal damage is much lesser in histological sections of specimen resected using Bipolar energy and interpretation of the grade is easier which is one of the most important prognosticators especially in bladder tumours since high grade lesions are proven beyond doubt to progress and recur.